Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF3 | O95398 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.83 |
| ▸ | PDE4A | P27815 | 15/20 | 0.80 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.80 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.80 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.80 |
| ▸ | PRKACA | P17612 | 2/20 | 0.80 |
| ▸ | PRKACG | P22612 | 2/20 | 0.80 |
| ▸ | PRKACB | P22694 | 2/20 | 0.80 |
| ▸ | BLM | P54132 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29381930 | 1.00 | RAPGEF3 (1.00) | RAPGEF3MEN1KMT2APDE4APDE4B | |
| SCHEMBL20636603 | 0.99 | RAPGEF3 (0.98) | RAPGEF3MEN1KMT2APDE4APDE4B | |
| SCHEMBL21581229 | 0.91 | MEN1 (1.00) | RAPGEF3MEN1KMT2APDE4APDE4B | |
| SCHEMBL30145615 | 0.91 | MEN1 (1.00) | RAPGEF3MEN1KMT2APDE4APDE4B | |
| SCHEMBL29381357 | 0.89 | PDE4A (1.00) | RAPGEF3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7521869 | 0.89 | PDE4A (1.00) | RAPGEF3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7950989 | 0.89 | PDE4A (1.00) | RAPGEF3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29887763 | 0.86 | PRKACA (0.85) | RAPGEF3MEN1KMT2APDE4APDE4B | |
| SCHEMBL17226783 | 0.83 | PDE4A (0.81) | RAPGEF3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL15626148 | 0.82 | RAPGEF3 (0.69) | RAPGEF3MEN1KMT2APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236523-B2 | Camp reporters and high throughput assays | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-08-07 | — | — | US | disclosed |
| US-20070111270-A1 | cAMP reporters and high throughput assays | THE JOHNS HOPKINS UNIVERSITY (US) | 2007-05-17 | — | — | US | disclosed |