Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 16/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 16/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 16/20 | 1.00 |
| ▸ | PRKACA | P17612 | 2/20 | 1.00 |
| ▸ | PRKACG | P22612 | 2/20 | 1.00 |
| ▸ | PRKACB | P22694 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 0.84 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7521869 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPRKACA | |
| SCHEMBL29381357 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPRKACA | |
| SCHEMBL29399288 | 0.91 | BLM (1.00) | PDE4APDE4BPDE4CPDE4DPRKACA | |
| SCHEMBL29478506 | 0.91 | BLM (1.00) | PDE4APDE4BPDE4CPDE4DPRKACA | |
| SCHEMBL30237695 | 0.91 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DPRKACA | |
| SCHEMBL5576482 | 0.89 | RAPGEF3 (1.00) | PDE4APDE4BPDE4CPDE4DPRKACA | |
| SCHEMBL29381930 | 0.89 | RAPGEF3 (1.00) | PDE4APDE4BPDE4CPDE4DPRKACA | |
| SCHEMBL20636603 | 0.88 | RAPGEF3 (0.98) | PDE4APDE4BPDE4CPDE4DPRKACA | |
| SCHEMBL29825773 | 0.87 | BLM (0.84) | PDE4APDE4BPDE4CPDE4DPRKACA | |
| Tocladesine SCHEMBL1651488 | 0.84 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147169-A1 | PHARMACEUTICL COMPOSITIONS USEFUL FOR THE TREATMENT OF CANCERS, IN PARTICULAR ACUTE MYELOID LEUKEMIA AND ACUTE PROMYELOCYTIC LEUKEMIA | UNIVERSITE PARIS DIDEROT-PARIS 7 (FR) | 2009-12-10 | — | — | WO | disclosed |