Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | LTK | P29376 | 1/20 | 0.51 |
| ▸ | GRK5 | P34947 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5576480 | 0.86 | NTRK1 (0.53) | NTRK1RETPRKD3ABL1DAPK3 | |
| SCHEMBL5576481 | 0.86 | NTRK1 (0.53) | NTRK1RETPRKD3ABL1DAPK3 | |
| SCHEMBL5576484 | 0.86 | NTRK1 (0.53) | NTRK1RETPRKD3ABL1DAPK3 | |
| SCHEMBL6015997 | 0.81 | MEN1 (0.60) | NTRK1RETPRKD3ABL1DAPK3 | |
| SCHEMBL6015995 | 0.81 | MEN1 (0.60) | NTRK1RETPRKD3ABL1DAPK3 | |
| SCHEMBL8207262 | 0.78 | ACHE (0.55) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL8207266 | 0.78 | ACHE (0.55) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL8186719 | 0.77 | SIRT2 (0.58) | KDM4ERAB9AMAPTALDH1A1LMNA | |
| SCHEMBL8186721 | 0.77 | SIRT2 (0.58) | KDM4ERAB9AMAPTALDH1A1LMNA | |
| SCHEMBL12537517 | 0.76 | PIK3CA (0.51) | NTRK1RETPRKD3ABL1DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070060606-A1 | Compounds and methods for modulating phosphodiesterase 10A | DALHOUSIE UNIVERSITY (CA) | 2007-03-15 | — | — | US | claimed |
| US-20070060606-A1 | Compounds and methods for modulating phosphodiesterase 10A | DALHOUSIE UNIVERSITY (CA) | 2007-03-15 | — | — | US | disclosed |
| US-20070060606-A1 | Compounds and methods for modulating phosphodiesterase 10A | DALHOUSIE UNIVERSITY (CA) | 2007-03-15 | — | — | US | disclosed |
| US-20070060606-A1 | Compounds and methods for modulating phosphodiesterase 10A | DALHOUSIE UNIVERSITY (CA) | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060606-A1 | Compounds and methods for modulating phosphodiesterase 10A | PDE7A, PDE10A, PDE2A | NTRK1 684/4885RET 1639/4885PRKD3 236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.