Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1837122 | 0.89 | KDM4E (0.59) | KDM4ERAB9ANPC1SMN1; SMN2POLB | |
| SCHEMBL13252193 | 0.78 | RAB9A (0.76) | KDM4ERAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL6037565 | 0.77 | KMT2A (0.59) | KDM4ERAB9ANPC1SMN1; SMN2POLB | |
| SCHEMBL21729904 | 0.77 | RAB9A (0.75) | KDM4ERAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL29484708 | 0.77 | RAB9A (0.75) | KDM4ERAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL10966689 | 0.75 | KDM4E (0.63) | KDM4ERAB9ANPC1SMN1; SMN2POLB | |
| SCHEMBL30475420 | 0.75 | GAA (0.58) | KDM4ENPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL30475423 | 0.75 | GAA (0.58) | KDM4ENPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13104367 | 0.75 | ALDH1A1 (0.51) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1690756 | 0.75 | ALDH1A1 (0.65) | KDM4ERAB9ANPC1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070015688-A1 | Method for screening for inhibitors of alzheimer's disease | PRANA BIOTECHNOLOGY LTD. (AU) | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015688-A1 | Method for screening for inhibitors of alzheimer's disease | APP, BACE1, PSEN1 | KDM4E 4743/4885RAB9A 4367/4885NPC1 168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.