Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4931500 | 0.82 | MEN1 (0.44) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL27422458 | 0.71 | HTR3E (0.64) | ALDH1A1MAPTDRD2DRD4LMNA | |
| SCHEMBL1748175 | 0.70 | ERN1 (0.66) | ALDH1A1ERN1MEN1KMT2AHPGD | |
| SCHEMBL14292141 | 0.70 | ERN1 (0.51) | ALDH1A1ERN1MEN1KMT2AHPGD | |
| SCHEMBL27250826 | 0.69 | ATR (0.37) | MAPTLMNAHTR3EHTR3BHTR3A | |
| SCHEMBL30925338 | 0.69 | ATR (0.37) | MAPTLMNAHTR3EHTR3BHTR3A | |
| SCHEMBL6413771 | 0.68 | ERN1 (0.53) | ALDH1A1ERN1MEN1KMT2AHPGD | |
| SCHEMBL31551028 | 0.68 | ERN1 (0.53) | ALDH1A1ERN1MEN1KMT2AHPGD | |
| SCHEMBL5577210 | 0.67 | NPSR1 (0.34) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL415808 | 0.67 | ERN1 (0.51) | ALDH1A1MAPTERN1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750727-A2 | KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005117909-A2 | KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-12-15 | — | — | WO | disclosed |