Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5577214 | 0.83 | ALDH1A1 (0.34) | NPSR1MAPTLMNAUSP2TSHR | |
| SCHEMBL4932445 | 0.77 | ADRB1 (0.50) | HTT | |
| SCHEMBL5577193 | 0.75 | USP2 (0.45) | LMNAUSP2ALDH1A1MEN1KMT2A | |
| SCHEMBL5577203 | 0.72 | RPS6KB1 (0.55) | MAPTKDM4E | |
| SCHEMBL11296569 | 0.69 | MAPT (0.66) | NPSR1MAPTLMNATSHRHTT | |
| SCHEMBL27422458 | 0.69 | HTR3E (0.64) | MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL17731762 | 0.68 | RPS6KB1 (0.40) | POLB | |
| SCHEMBL4433463 | 0.68 | POLB (0.69) | MAPTLMNATSHRHTTALDH1A1 | |
| SCHEMBL5577183 | 0.67 | ALDH1A1 (0.39) | MAPTLMNATSHRALDH1A1MEN1 | |
| SCHEMBL12752842 | 0.67 | ADRB1 (0.53) | LMNAHTTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750727-A2 | KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005117909-A2 | KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-12-15 | — | — | WO | disclosed |