Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5577941 | 0.84 | HSD11B1 (0.40) | HSD11B1PIK3CAJAK2ALDH1A1LMNA | |
| SCHEMBL5577959 | 0.82 | JAK2 (0.35) | HSD11B1JAK2ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL5577960 | 0.82 | GPBAR1 (0.36) | JAK2IKBKBPARP1CSNK2A2KDR | |
| SCHEMBL14454989 | 0.81 | MEN1 (0.44) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL14473199 | 0.69 | MEN1 (0.38) | ALDH1A1NPC1SMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL5577940 | 0.67 | ALDH1A1 (0.37) | HSD11B1PIK3CAALDH1A1LMNANPC1 | |
| SCHEMBL3501617 | 0.66 | GRM2 (0.38) | ALDH1A1LMNANPC1RAB9AHSD17B10 | |
| SCHEMBL4753950 | 0.66 | CA1 (0.41) | ALDH1A1LMNANPC1SMN1; SMN2RAB9A | |
| SCHEMBL5577957 | 0.65 | LIMK1 (0.44) | ALDH1A1LMNANPC1SMN1; SMN2RAB9A | |
| SCHEMBL5577966 | 0.65 | HSD11B1 (0.35) | HSD11B1JAK2ALDH1A1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070173488-A1 | Pyrazolothiazole Protein Kinase Modulators | SGX PHARMACEUTICALS, INC. (US) | 2007-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173488-A1 | Pyrazolothiazole Protein Kinase Modulators | MAP4K2, MAP4K5, MAP4K3 | HSD11B1 3411/4885PIK3CA 211/4885JAK2 182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.