Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | OGA | O60502 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | MAT2A | P31153 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5579349 | 0.80 | HDAC1 (0.49) | ALDH1A1TSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5737098 | 0.77 | NPC1 (0.53) | EPHX2POLBMAPTMEN1KMT2A | |
| SCHEMBL17898129 | 0.76 | KMT2A (0.57) | EPHX2POLBMAPTMEN1KMT2A | |
| SCHEMBL19844524 | 0.74 | L3MBTL1 (0.68) | POLBMAPTMEN1KMT2ANPC1 | |
| SCHEMBL19844525 | 0.74 | L3MBTL1 (0.68) | POLBMAPTMEN1KMT2ANPC1 | |
| SCHEMBL19844532 | 0.74 | L3MBTL1 (0.68) | POLBMAPTMEN1KMT2ANPC1 | |
| SCHEMBL19844533 | 0.74 | L3MBTL1 (0.68) | POLBMAPTMEN1KMT2ANPC1 | |
| Bromide SCHEMBL11429498 | 0.72 | ALDH1A1 (0.58) | POLBNPC1ALDH1A1GAAHTT | |
| SCHEMBL23007438 | 0.71 | CYP2C9 (0.47) | POLBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL25122224 | 0.71 | CYP2C9 (0.47) | POLBMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236756-B2 | HIV protease inhibitory compounds with ameliorated solubility and/or bioavailability; conjugates of therapeutic compound and a peptide wherein the conjugate is cleavable by dipeptidyl-peptidases | Consejo Superior de Investigaciones Clentificas (CSIC) (ES) | 2012-08-07 | — | — | US | disclosed |
| US-20070275900-A1 | Prodrugs Cleavable by Cd26 | K.U. LEUVEN RESEARCH & DEVELOPMENT (BE) | 2007-11-29 | — | — | US | disclosed |
| US-20070275900-A1 | Prodrugs Cleavable by Cd26 | K.U. LEUVEN RESEARCH & DEVELOPMENT (BE) | 2007-11-29 | — | — | US | disclosed |
| EP-1620130-A1 | PRODRUGS CLEAVABLE BY CD26 | K.U. Leuven Research & Development (BE) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004098644-A1 | PRODRUGS CLEAVABLE BY CD26 | K.U. LEUVEN RESEARCH & DEVELOPMENT (BE) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275900-A1 | Prodrugs Cleavable by Cd26 | DPP4, DNPEP, DPP3 | EPHX2 2006/4885POLB 4822/4885MAPT 2392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.