Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 6/20 | 0.38 |
| ▸ | CTSD | P07339 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CETP | P11597 | 2/20 | 0.34 |
| ▸ | CTSB | P07858 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5125902 | 0.94 | KMT2A (0.41) | PPARABACE1CTSDLMNAHDAC3 | |
| SCHEMBL5130327 | 0.89 | BACE1 (0.40) | BACE1CTSDLMNAHDAC3HDAC4 | |
| SCHEMBL5131035 | 0.86 | LMNA (0.41) | BACE1CTSDLMNAHDAC3HDAC4 | |
| SCHEMBL5120921 | 0.85 | HTT (0.42) | BACE1CTSDKMT2AMEN1ALDH1A1 | |
| SCHEMBL5116565 | 0.85 | BACE1 (0.38) | BACE1CTSDLMNAHDAC3HDAC4 | |
| SCHEMBL5131129 | 0.85 | POLB (0.41) | BACE1CTSDHDAC3HDAC1KMT2A | |
| SCHEMBL5126595 | 0.83 | LMNA (0.41) | BACE1CTSDLMNAKMT2AMEN1 | |
| SCHEMBL5120535 | 0.82 | EPHX2 (0.41) | BACE1CTSDHDAC3HDAC4HDAC1 | |
| SCHEMBL5130825 | 0.82 | BACE1 (0.45) | BACE1CTSDCTSB | |
| SCHEMBL5125565 | 0.81 | BACE1 (0.39) | BACE1CTSDCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294642-B2 | 1,3-Diamino-2-hydroxypropane pro-drug derivatives | ELAN PHARMACEUTICALS, INC. (US) | 2007-11-13 | — | — | US | disclosed |