Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.52 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.52 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31291173 | 1.00 | EHMT2 (0.52) | EHMT2EHMT1APOBEC3GHDAC1HDAC2 | |
| SCHEMBL27398355 | 1.00 | EHMT2 (0.52) | EHMT2EHMT1APOBEC3GHDAC1HDAC2 | |
| SCHEMBL1039828 | 1.00 | EHMT2 (0.52) | EHMT2EHMT1APOBEC3GHDAC1HDAC2 | |
| SCHEMBL19104359 | 1.00 | EHMT2 (0.52) | EHMT2EHMT1APOBEC3GHDAC1HDAC2 | |
| SCHEMBL3487114 | 1.00 | EHMT2 (0.52) | EHMT2EHMT1APOBEC3GHDAC1HDAC2 | |
| SCHEMBL23963850 | 1.00 | EHMT2 (0.52) | EHMT2EHMT1APOBEC3GHDAC1HDAC2 | |
| SCHEMBL10077568 | 1.00 | EHMT2 (0.52) | EHMT2EHMT1APOBEC3GHDAC1HDAC2 | |
| SCHEMBL463670 | 0.98 | EHMT2 (0.53) | EHMT2EHMT1APOBEC3GHDAC1HDAC2 | |
| SCHEMBL12107793 | 0.93 | EHMT2 (0.55) | EHMT2EHMT1APOBEC3GHDAC1HDAC2 | |
| SCHEMBL30195173 | 0.93 | EHMT2 (0.55) | EHMT2EHMT1APOBEC3GHDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191274-A1 | Active hedgehog protein conjugate | ONTOGENY, INC. | 2007-08-16 | — | — | US | disclosed |
| US-7153836-B2 | Active hedgehog protein conjugate | CURIS, INC. (US) | 2006-12-26 | — | — | US | disclosed |
| EP-0953576-B1 | Active hedgehog protein conjugate, process for its production and use | CURIS INC (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-1557427-A2 | Hedgehog protein conjugate | Curis, Inc. (US) | 2005-07-27 | — | — | EP | disclosed |
| US-20050148510-A1 | Active hedgehog protein conjugate | CURIS, INC. (US) | 2005-07-07 | — | — | US | disclosed |
| US-6818623-B2 | COMPRISES MORPHOGENIC TRANSMEMBRANE POLYPEPTIDE WITH INCREASED ACTIVITY FOR TREATING BONE, NEURODEGENERATIVE AND MUSCLE DISORDERS | CURIS, INC. | 2004-11-16 | — | — | US | disclosed |
| US-20030139574-A1 | Active hedgehog protein conjugate | ROCHE DIAGNOSTICS GMBH (DE) | 2003-07-24 | — | — | US | disclosed |
| US-6468978-B1 | CONJUGATE COMPRISING 1 TO 4 MOIETIES COVALENTLY BOUND TO POLYPEPTIDE COMPRISING HEDGEHOG N-TERMINAL DOMAIN, EACH BEING POLYPEPTIDE CONTAINING 10 TO 30 HYDROPHOBIC AMINO ACIDS OR POSITIVELY CHARGED AMINO ACIDS FORMING TRANSMEMBRANE HELICES | CURIS, INC. | 2002-10-22 | — | — | US | disclosed |
| EP-0953576-A1 | Active hedgehog protein conjugate, process for its production and use | BOEHRINGER MANNHEIM GMBH (DE) | 1999-11-03 | — | — | EP | disclosed |