SCHEMBL463670

SCHEMBL463670

CCCCCSSc1ccccn1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EHMT2 Q96KQ7 1/20 0.53
EHMT1 Q9H9B1 1/20 0.53
APOBEC3G Q9HC16 1/20 0.53
HDAC1 Q13547 9/20 0.41
HDAC2 Q92769 7/20 0.41
HDAC4 P56524 2/20 0.41
HDAC6 Q9UBN7 1/20 0.41
ALDH1A1 P00352 1/20 0.39
LMNA P02545 3/20 0.39
KDM4E B2RXH2 2/20 0.39
USP2 O75604 1/20 0.39
ALOX15 P16050 1/20 0.39
ALOX12 P18054 1/20 0.39
HTT P42858 1/20 0.39
NPC1 O15118 1/20 0.39
HSP90AA1 P07900 1/20 0.39
RAB9A P51151 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
CYP1A2 P05177 1/20 0.38
CYP2D6 P10635 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10077568 0.98 EHMT2 (0.52) EHMT2EHMT1APOBEC3GHDAC1HDAC2
SCHEMBL27398355 0.98 EHMT2 (0.52) EHMT2EHMT1APOBEC3GHDAC1HDAC2
SCHEMBL31291173 0.98 EHMT2 (0.52) EHMT2EHMT1APOBEC3GHDAC1HDAC2
SCHEMBL1039828 0.98 EHMT2 (0.52) EHMT2EHMT1APOBEC3GHDAC1HDAC2
SCHEMBL3487114 0.98 EHMT2 (0.52) EHMT2EHMT1APOBEC3GHDAC1HDAC2
SCHEMBL23963850 0.98 EHMT2 (0.52) EHMT2EHMT1APOBEC3GHDAC1HDAC2
SCHEMBL19104359 0.98 EHMT2 (0.52) EHMT2EHMT1APOBEC3GHDAC1HDAC2
SCHEMBL5580067 0.98 EHMT2 (0.52) EHMT2EHMT1APOBEC3GHDAC1HDAC2
SCHEMBL12107793 0.95 EHMT2 (0.55) EHMT2EHMT1APOBEC3GHDAC1HDAC2
SCHEMBL30195173 0.95 EHMT2 (0.55) EHMT2EHMT1APOBEC3GHDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024119098-A1 LIPID NANOPARTICLE (LNP) DELIVERY SYSTEMS AND FORMULATIONS PRIME MEDICINE, INC. (US) 2024-06-06 WO disclosed
US-11981703-B2 Polynucleotide constructs SIRIUS THERAPEUTICS, INC. (US) 2024-05-14 US disclosed
US-20200392498-A1 POLYNUCLEOTIDE CONSTRUCTS HAVING BIOREVERSIBLE AND NON-BIOREVERSIBLE GROUPS SOLSTICE BIOLOGICS LTD (IE) 2020-12-17 US disclosed
US-20190202855-A1 POLYNUCLEOTIDE CONSTRUCTS SIRIUS THERAPEUTICS, INC. 2019-07-04 US disclosed
EP-3500581-A1 POLYNUCLEOTIDE CONSTRUCTS Solstice Biologics, Ltd. (IE) 2019-06-26 EP disclosed
WO-2018035380-A1 POLYNUCLEOTIDE CONSTRUCTS SOLSTICE BIOLOGICS, LTD. (IE) 2018-02-22 WO disclosed
US-20180021454-A1 TARGETED CONJUGATES ENCAPSULATED IN PARTICLES AND FORMULATIONS THEREOF TVA (ABC), LLC 2018-01-25 US disclosed
US-9763995-B2 Polymer conjugates of protegrin peptides NEKTAR THERAPEUTICS (US) 2017-09-19 US disclosed
US-20170196975-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY NEKTAR THERAPEUTICS 2017-07-13 US disclosed
US-9682153-B2 Polymer conjugates of therapeutic peptides NEKTAR THERAPEUTICS (US) 2017-06-20 US disclosed
US-20110206633-A1 POLYMER CONJUGATES OF CD-NP PEPTIDES Nektar Therapectics (US) 2011-08-25 US disclosed
US-20100021481-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY NEKTAR THERAPEUTICS (US) 2010-01-28 US disclosed
US-20070092482-A1 Conjugates of a G-CSF moiety and a polymer NEKTAR THERAPEUTICS 2007-04-26 US disclosed
EP-1590317-B1 ENANTIOMER-PURE (4S,8S)- AND (4R, 8R)-4-P-NITROBENZYL-8-METHYL-3, 6, 9-TRIAZA- SP 3 /sp N, SP 6 /SP N, SP 9 /SP N-TRICARBOXYMETHYL-1, 11-UNDECANOIC ACID AND DERIVATIVES THEREOF, METHOD FOR PRODUCING THEM, AND THEIR USE FOR PRODUCING PHARMACEUTICAL AGENTS SCHERING AG (DE) 2007-01-24 EP disclosed
WO-2004108678-A1 (1,2,3,4-TETRAHYDROQUINOLIN-8-YL)-HEPTATRIENOIC ACID DERIVATIVES HAVING SERUM GLUCOSE REDUCING ACTIVITY ALLERGAN, INC. (US) 2004-12-16 WO disclosed
US-20040220231-A1 Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity LEE LEN F (US) 2004-11-04 US disclosed
US-6794396-B2 Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity PHARMACIA CORPORATION 2004-09-21 US disclosed
US-20040038939-A1 Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity PHARMACIA CORPORATION 2004-02-26 US disclosed
US-6605624-B1 Preventing and/or treating atherosclerosis and other coronary artery diseases PHARMACIA CORPORATION 2003-08-12 US disclosed
WO-1999041237-A1 SUBSTITUTED PYRIDINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY G.D. SEARLE & CO. (US) 1999-08-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110206633-A1 POLYMER CONJUGATES OF CD-NP PEPTIDES CD63, CLSPN, LNPEP EHMT2 4657/4885EHMT1 4594/4885APOBEC3G 2487/4885
US-20200392498-A1 POLYNUCLEOTIDE CONSTRUCTS HAVING BIOREVERSIBLE AND NON-BIOREVERSIBLE GROUPS HNRNPC, RNASE1, NSUN3 EHMT2 3919/4885EHMT1 4358/4885APOBEC3G 234/4885
US-20100021481-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY TNF, TNFRSF1A, TNFRSF9 EHMT2 4337/4885EHMT1 4185/4885APOBEC3G 2236/4885
US-11981703-B2 Polynucleotide constructs PHAX, CPSF6, RNGTT EHMT2 4639/4885EHMT1 4841/4885APOBEC3G 1360/4885
US-20170196975-A1 CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY TNF, TNFRSF1A, TNFRSF9 EHMT2 4311/4885EHMT1 4171/4885APOBEC3G 2475/4885
US-20040038939-A1 Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity CETP, CES1, MTTP EHMT2 4145/4885EHMT1 3628/4885APOBEC3G 4577/4885
US-20040220231-A1 Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity CETP, MTTP, LCAT EHMT2 4147/4885EHMT1 3943/4885APOBEC3G 4517/4885
US-20070092482-A1 Conjugates of a G-CSF moiety and a polymer CSF3R, GMFG, CSF1R EHMT2 2267/4885EHMT1 2192/4885APOBEC3G 2021/4885
US-20190202855-A1 POLYNUCLEOTIDE CONSTRUCTS PHAX, CPSF6, RNGTT EHMT2 4639/4885EHMT1 4841/4885APOBEC3G 1360/4885
US-20180021454-A1 TARGETED CONJUGATES ENCAPSULATED IN PARTICLES AND FORMULATIONS THEREOF CD47, CD44, FURIN EHMT2 3563/4885EHMT1 3717/4885APOBEC3G 3177/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.