Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7779540 | 0.74 | MAPK10 (0.31) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL3517499 | 0.72 | KDM4E (0.37) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL5726226 | 0.72 | BRD4 (0.41) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL5725670 | 0.71 | CYP19A1 (0.32) | — | |
| SCHEMBL1658069 | 0.69 | ESR2 (0.51) | — | |
| SCHEMBL5581724 | 0.68 | ESR2 (0.44) | — | |
| SCHEMBL10932268 | 0.68 | — | — | |
| SCHEMBL13418998 | 0.68 | KDM4E (0.42) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL28335018 | 0.68 | KDM4E (0.39) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL23562998 | 0.67 | KDM4E (0.35) | KDM4EALDH1A1HPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070087346-A1 | Orthogonal gene switches | CILIBERTO GENNARO | 2007-04-19 | — | — | US | disclosed |
| US-20070087346-A1 | Orthogonal gene switches | CILIBERTO GENNARO | 2007-04-19 | — | — | US | disclosed |
| US-20070087346-A1 | Orthogonal gene switches | CILIBERTO GENNARO | 2007-04-19 | — | — | US | disclosed |
| EP-1680447-A2 | ORTHOGONAL GENE SWITCHES | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2006-07-19 | — | — | EP | disclosed |
| EP-1339683-B1 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO INC (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005040212-A2 | ORTHOGONAL GENE SWITCHES | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070087346-A1 | Orthogonal gene switches | TCF12, JUN, TCF7 | KDM4E 2706/4885ALDH1A1 3117/4885HPGD 3386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.