TCF7 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL178745	1.00	2/20
SCHEMBL4865597	1.00	2/20
SCHEMBL4865605	1.00	2/20
SCHEMBL13744871	1.00	2/20
SCHEMBL13745272	0.85	2/20
SCHEMBL12483974	0.84	2/20
SCHEMBL12485555	0.82	2/20
SCHEMBL1285350	0.80	2/20
SCHEMBL8739100	0.78	2/20
SCHEMBL2550854	0.75	2/20
SCHEMBL13028973	0.75	2/20
SCHEMBL747784	0.74	2/20
SCHEMBL750985	0.74	2/20
SCHEMBL12485186	0.72	2/20
SCHEMBL402163	0.71	2/20
SCHEMBL13744995	0.71	2/20
SCHEMBL12222035	0.70	2/20
SCHEMBL749351	0.69	2/20
SCHEMBL763057	0.69	2/20
SCHEMBL1286164	0.68	2/20

Clinical trials — most relevant to TCF7 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Latency in Pulmonary Tuberculosis	PHASE3	COMPLETED
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized)	PHASE3	UNKNOWN
Elimusertib for the Treatment of Relapsed or Refractory Solid Tumors	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
The Effect of rs7903146 Genotype on Islet GLP-1 Production in Humans	PHASE2	NOT_YET_RECRUITING
CD7 CAR-T Combined With Autologous Hematopoietic Stem Cell Transplantation	PHASE1/PHASE2	NOT_YET_RECRUITING
Biomarker Driven Intensified ChemoImmunotherapy With Early CNS Prophylaxis	PHASE2	ACTIVE_NOT_RECRUITING
Multiple Intracerebral Doses of Neural Stem Cell-Based Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas	PHASE1	SUSPENDED
Safety and Efficacy Study of PRI-724 Plus Gemcitabine in Subjects With Advanced or Metastatic Pancreatic Adenocarcinoma	PHASE1	COMPLETED
Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC)	PHASE1	COMPLETED
Can Gluten-free Diet Prevent the Destruction of Beta-cells During Remission?	EARLY_PHASE1	UNKNOWN
A Pilot Study of Berberine (Soloways ™) in Patients with Type 2 Diabetes Mellitus Carrying TCF7L2 Polymorphisms	nan	COMPLETED
Immunophenotypic Evaluation of IL-7R α in Acute Leukaemia	nan	UNKNOWN
RORC Genetic Polymorphism of Rheumatoid Arthritis	nan	COMPLETED
Tissue Expression of Krüppel-Like Factors 4 and 7 in Bone Tumors	nan	RECRUITING
Study on the Interplay Between Twist1 and Other EMT Regulators Through microRNA-29 Family.	nan	UNKNOWN
Pathogenesis of Youth Onset Type 2 Diabetes and Prediabetes	nan	COMPLETED
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
Detection of IKZF1 Deletion Mutation in Patients With Acute Lymphoblastic Leukemia and Its Impact in Therapy	nan	UNKNOWN
Explore the Role of NLRP7 in the Regulation of Progestereone Induced Decidualization of Human Endometrial Stroma Cells	nan	COMPLETED
Model to Predict pCR and IrAEs in Early Stage Non-small Cell Lung Cancer	nan	UNKNOWN
CD7 CAR-T Cells in T-cell Lymphoma/Leukemia	nan	RECRUITING
Transcriptomic Responses for the Identification of Pathogens	nan	RECRUITING
LEF1 EXPRESSION IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS: A MARKER FOR DIAGNOSIS AND SURVIVAL PREDICTION	nan	RECRUITING
Dd-cfDNA and Treg in Prediction of Kidney Transplant Acute Rejection	nan	RECRUITING
Effects of Mulberry Juice on Inflammatory Status and Clinical Symptoms in Patients With General Anxiety Disorder	nan	UNKNOWN
Epithelial Mesenchymal Transition and Periodontitis	nan	UNKNOWN
Epigenomic Profiling of Circulating Cell-Free DNA (cfDNA) to Characterize the Dynamic Evolution of Molecular Subtypes in Extensive-Stage Small Cell Lung Cancer During First-Line Chemoimmunotherapy	nan	NOT_YET_RECRUITING
CD7 CAR-T Cell Therapy Targeting CD7-positive Relapsed/Refractory T Cell Lymphoma/Acute Leukemia	nan	NOT_YET_RECRUITING
The Role of Dietary Tryptophan on Aryl Hydrocarbon Receptor Activation	nan	COMPLETED
Genetic Variation in TRAF3IP2 (rs13190932)	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a TCF7 binder may also engage these)

Protein	Name	Similarity
Q00417	—	1.000	Q00417 →
Q04888	—	0.998	Q04888 →
P48435	—	0.996	P48435 →
O55170	—	0.996	O55170 →
O95096	—	0.996	O95096 →
Q99958	—	0.996	Q99958 →
A2D4R4	—	0.996	A2D4R4 →
A2D4P8	—	0.995	A2D4P8 →
P78414	—	0.995	P78414 →
A2D649	—	0.995	A2D649 →
P57073	—	0.995	P57073 →
Q9Z1J1	—	0.995	Q9Z1J1 →
Q92858	—	0.995	Q92858 →
P14653	—	0.994	P14653 →
P24899	—	0.994	P24899 →
P31277	—	0.994	P31277 →
P17483	—	0.994	P17483 →
O55144	—	0.994	O55144 →
Q2VWA4	—	0.994	Q2VWA4 →
A2T6H5	—	0.994	A2T6H5 →
P48031	—	0.994	P48031 →
P57074	—	0.994	P57074 →
P52954	—	0.994	P52954 →
A2T7J2	—	0.994	A2T7J2 →
P19091	—	0.994	P19091 →
Q8CGW4	—	0.994	Q8CGW4 →
P43697	—	0.994	P43697 →
P23813	—	0.994	P23813 →
P52945	—	0.994	P52945 →
Q9HCS4	—	0.993	Q9HCS4 →