Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 13/20 | 0.84 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.84 |
| ▸ | EBP | Q15125 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5582312 | 0.92 | ESR1 (1.00) | ESR1ESR2 | |
| SCHEMBL5582338 | 0.85 | ESR1 (0.61) | ESR1ESR2MAOB | |
| SCHEMBL2417053 | 0.85 | ESR2 (0.62) | ESR1ESR2EBPSIGMAR1HRH3 | |
| SCHEMBL5582427 | 0.84 | ESR1 (0.68) | ESR1ESR2 | |
| SCHEMBL2418189 | 0.78 | ESR2 (0.75) | ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL2419390 | 0.78 | ESR2 (0.74) | ESR1ESR2 | |
| SCHEMBL2422287 | 0.77 | ESR2 (0.74) | ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL2418710 | 0.77 | ESR2 (0.73) | ESR1ESR2 | |
| SCHEMBL5582320 | 0.76 | ESR1 (0.59) | ESR1ESR2 | |
| SCHEMBL2424862 | 0.75 | ESR2 (0.70) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070087346-A1 | Orthogonal gene switches | CILIBERTO GENNARO | 2007-04-19 | — | — | US | disclosed |
| EP-1680447-A2 | ORTHOGONAL GENE SWITCHES | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005040212-A2 | ORTHOGONAL GENE SWITCHES | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070087346-A1 | Orthogonal gene switches | TCF12, JUN, TCF7 | ESR1 329/4885ESR2 280/4885EBP 252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.