Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 17/20 | 1.00 |
| ▸ | ESR1 | P03372 | 17/20 | 0.67 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.57 |
| ▸ | AR | P10275 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5582360 | 0.84 | ESR2 (0.72) | ESR2ESR1NR3C1AR | |
| SCHEMBL22309467 | 0.81 | ESR2 (1.00) | ESR2ESR1 | |
| SCHEMBL11118130 | 0.78 | ESR2 (0.64) | ESR2ESR1NR3C1AR | |
| SCHEMBL5582158 | 0.77 | ESR2 (1.00) | ESR2ESR1 | |
| SCHEMBL5582489 | 0.75 | ESR2 (0.60) | ESR2ESR1NR3C1AR | |
| SCHEMBL14547385 | 0.75 | ESR2 (1.00) | ESR2ESR1 | |
| SCHEMBL14547387 | 0.73 | ESR2 (1.00) | ESR2ESR1 | |
| SCHEMBL4855050 | 0.72 | ESR2 (0.84) | ESR2ESR1 | |
| SCHEMBL3291858 | 0.72 | AR (1.00) | ESR2ESR1NR3C1AR | |
| SCHEMBL3284537 | 0.72 | AR (1.00) | ESR2ESR1NR3C1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070087346-A1 | Orthogonal gene switches | CILIBERTO GENNARO | 2007-04-19 | — | — | US | disclosed |
| EP-1680447-A2 | ORTHOGONAL GENE SWITCHES | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005040212-A2 | ORTHOGONAL GENE SWITCHES | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070087346-A1 | Orthogonal gene switches | TCF12, JUN, TCF7 | ESR2 280/4885ESR1 329/4885NR3C1 1021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.