Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTMT1 | Q9BV86 | 2/20 | 0.53 |
| ▸ | Q9HBH1 | 1/20 | 0.52 | |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11417445 | 0.94 | NTMT1 (0.55) | NTMT1PDFF2SSTR3TACR1 | |
| SCHEMBL11423847 | 0.91 | NTMT1 (0.51) | NTMT1PDFF2SSTR3TACR1 | |
| SCHEMBL1100531 | 0.89 | PDF (0.49) | NTMT1PDFF2SSTR3TACR1 | |
| SCHEMBL5874068 | 0.88 | NTMT1 (0.44) | NTMT1PDFF2TACR1HDAC3 | |
| Acetic Acid SCHEMBL7018491 | 0.86 | TACR1 (0.43) | NTMT1PDFSSTR3TACR1HDAC3 | |
| SCHEMBL263537 | 0.85 | PDF (0.46) | NTMT1PDFF2SSTR3TACR1 | |
| SCHEMBL29427848 | 0.85 | PDF (0.46) | NTMT1PDFF2SSTR3TACR1 | |
| SCHEMBL11418081 | 0.84 | NTMT1 (0.47) | NTMT1PDFF2SSTR3TACR1 | |
| Acetic Acid SCHEMBL16234756 | 0.84 | PDF (0.44) | NTMT1PDFF2SSTR3TACR1 | |
| Hydrochloric Acid SCHEMBL11425398 | 0.83 | NTMT1 (0.46) | NTMT1PDFF2SSTR3TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807082-A2 | FACTOR XA COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006047415-A2 | FACTOR XA COMPOUNDS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-04 | — | — | WO | disclosed |
| US-5223422-A | T-PA MUTANT GK1L | BOEHRINGER MANNHEIM GMBH (DE) | 1993-06-29 | — | — | US | disclosed |