Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.49 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.49 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1957530 | 0.84 | MAPK1 (0.61) | MAPK1CYP11B1CYP11B2CYP19A1MAPT | |
| SCHEMBL4506543 | 0.84 | CYP11B2 (0.68) | MAPK1CYP11B1CYP11B2CYP19A1MAPT | |
| SCHEMBL30150593 | 0.82 | RAB9A (0.62) | MAPK1MAPTCHRNB2CHRNA4MEN1 | |
| SCHEMBL1323646 | 0.82 | RAB9A (0.62) | MAPK1MAPTCHRNB2CHRNA4MEN1 | |
| SCHEMBL8512404 | 0.82 | MAOB (0.56) | MAPK1MAPTCYP3A4MEN1KMT2A | |
| SCHEMBL6833618 | 0.81 | AKT1 (0.68) | MAPK1CYP11B1CYP11B2IKBKBCYP3A4 | |
| SCHEMBL12129613 | 0.81 | GRM5 (0.62) | MAPK1CYP11B1CYP11B2CYP19A1GRM5 | |
| Bromide SCHEMBL27462942 | 0.80 | RAB9A (0.60) | MAPK1MAPTCHRNB2CHRNA4MEN1 | |
| SCHEMBL27650249 | 0.80 | INPPL1 (0.53) | CYP11B1CYP11B2CYP19A1GRM5CHRNB2 | |
| SCHEMBL30338964 | 0.80 | CYP11B1 (0.70) | MAPK1CYP11B1CYP11B2CYP19A1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070027321-A1 | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2007-02-01 | — | — | US | disclosed |
| EP-1664018-A1 | BIPYRIDYL AMINES AND ETHERS AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | Merck & Co., Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005021529-A1 | BIPYRIDYL AMINES AND ETHERS AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO., INC. (US) | 2005-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027321-A1 | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 | GRM5, GRIK5, GRM1 | MAPK1 2462/4885CYP11B1 1221/4885CYP11B2 1381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.