Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | RORB | Q92753 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27703048 | 0.89 | HTR1A (0.36) | HTR1AHTR7PARP10PARP11CHRM3 | |
| SCHEMBL4596605 | 0.88 | ENPP1 (0.36) | HTR1AHTR7 | |
| SCHEMBL27703084 | 0.88 | GAA (0.41) | HTR1AHTR7KDM4EMAPTCHRM3 | |
| SCHEMBL4761887 | 0.87 | HTR1A (0.48) | HTR1AHTR7PARP10PARP11NOTUM | |
| SCHEMBL27703043 | 0.84 | AGXT (0.36) | HTR1AHTR7HTR2CIDO1 | |
| SCHEMBL27703110 | 0.84 | NPSR1 (0.45) | HTR1AHTR7KDM4EMAPTL3MBTL1 | |
| SCHEMBL27703072 | 0.84 | TDP2 (0.38) | PARP10KDM4EMAPT | |
| SCHEMBL27723763 | 0.81 | NPC1 (0.42) | — | |
| SCHEMBL4762814 | 0.81 | NTRK1 (0.32) | — | |
| SCHEMBL27703083 | 0.80 | PTGDR2 (0.38) | KDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101448492-A | Methods of treating cognitive and other disorders | WYETH CORP (US) | 2009-06-03 | — | — | CN | claimed |
| CN-101389325-A | Treatment of drug abuse | WYETH CORP (US) | 2009-03-18 | — | — | CN | claimed |
| CN-101203217-A | Methods for modulating bladder function | WYETH CORP (US) | 2008-06-18 | — | — | CN | claimed |
| CN-101198322-A | Novel therapeutic combinations for the treatment or prevention of depression | WYETH CORP (US) | 2008-06-11 | — | — | CN | claimed |
| CN-101198323-A | Therapeutic combinations for the treatment or prevention of psychotic disorders | WYETH CORP (US) | 2008-06-11 | — | — | CN | claimed |
| CN-101189004-A | Treatment of pain | WYETH CORP (US) | 2008-05-28 | — | — | CN | claimed |
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |
| CN-101448492-A | Methods of treating cognitive and other disorders | WYETH CORP (US) | 2009-06-03 | — | — | CN | disclosed |
| CN-101389325-A | Treatment of drug abuse | WYETH CORP (US) | 2009-03-18 | — | — | CN | disclosed |
| CN-101203217-A | Methods for modulating bladder function | WYETH CORP (US) | 2008-06-18 | — | — | CN | disclosed |
| CN-101203216-A | Dihydrobenzofuran derivatives and uses thereof | WYETH CORP (US) | 2008-06-18 | — | — | CN | disclosed |
| CN-101198322-A | Novel therapeutic combinations for the treatment or prevention of depression | WYETH CORP (US) | 2008-06-11 | — | — | CN | disclosed |
| CN-101198323-A | Therapeutic combinations for the treatment or prevention of psychotic disorders | WYETH CORP (US) | 2008-06-11 | — | — | CN | disclosed |
| CN-101189004-A | Treatment of pain | WYETH CORP (US) | 2008-05-28 | — | — | CN | disclosed |