Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.36 |
| ▸ | GCGR | P47871 | 6/20 | 0.35 |
| ▸ | GIPR | P48546 | 4/20 | 0.35 |
| ▸ | MRE11 | P49959 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | CPB1 | P15086 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 4/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL5585383 | 1.00 | ITGB3 (0.36) | ITGB3ITGA2BGCGRGIPRMRE11 | |
| Lysine SCHEMBL5585365 | 0.91 | FFAR1 (0.40) | ITGB3ITGA2BKDM4EALDH1A1 | |
| Lysine SCHEMBL5585366 | 0.91 | FFAR1 (0.40) | ITGB3ITGA2BKDM4EALDH1A1 | |
| SCHEMBL5585385 | 0.89 | MRE11 (0.34) | ITGB3ITGA2BGCGRGIPRMRE11 | |
| SCHEMBL5585392 | 0.89 | RXRA (0.42) | ITGB3ITGA2BGCGRGIPRMRE11 | |
| SCHEMBL6000638 | 0.89 | RXRA (0.42) | ITGB3ITGA2BGCGRGIPRMRE11 | |
| Hydrochloric Acid SCHEMBL5585448 | 0.88 | RXRA (0.41) | ITGB3ITGA2BGCGRGIPRMRE11 | |
| SCHEMBL5585528 | 0.88 | RXRA (0.41) | ITGB3ITGA2BGCGRGIPRMRE11 | |
| SCHEMBL5585241 | 0.88 | RXRA (0.41) | ITGB3ITGA2BGCGRGIPRMRE11 | |
| SCHEMBL5585463 | 0.88 | RXRA (0.43) | ITGB3ITGA2BGCGRGIPRMRE11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7163952-B2 | Azole compound and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2007-01-16 | — | — | US | disclosed |
| US-20050065196-A1 | Azole compound and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2005-03-24 | — | — | US | disclosed |
| EP-1452530-A1 | AZOLE COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2004-09-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065196-A1 | Azole compound and medicinal use thereof | PTPN7, PTPN1, PTPN5 | ITGB3 4100/4885ITGA2B 4054/4885GCGR 317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.