Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.48 |
| ▸ | PHGDH | O43175 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 4/20 | 0.43 |
| ▸ | MAOA | P21397 | 4/20 | 0.43 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | KDM1B | Q8NB78 | 4/20 | 0.43 |
| ▸ | RCOR1 | Q9UKL0 | 4/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14601442 | 0.99 | NPC1 (0.49) | NPC1RAB9ACHEK1PHGDHMEN1 | |
| SCHEMBL14601438 | 0.92 | MAPT (0.48) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL5585502 | 0.91 | NPC1 (0.47) | NPC1RAB9ACHEK1PHGDHMEN1 | |
| SCHEMBL14601435 | 0.91 | LMNA (0.53) | NPC1RAB9APHGDHMAPTHPGD | |
| Hydrochloric Acid SCHEMBL5585570 | 0.91 | MAPT (0.48) | NPC1RAB9AMEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL5585774 | 0.90 | LMNA (0.52) | NPC1RAB9APHGDHKDM1AMAOA | |
| SCHEMBL14601439 | 0.89 | USP2 (0.45) | NPC1RAB9AMEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL5585950 | 0.89 | USP2 (0.44) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL5585503 | 0.89 | RAB9A (0.46) | NPC1RAB9ACHEK1PHGDHMEN1 | |
| SCHEMBL14601440 | 0.86 | NPC1 (0.41) | NPC1RAB9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7163952-B2 | Azole compound and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2007-01-16 | — | — | US | disclosed |
| US-20050065196-A1 | Azole compound and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2005-03-24 | — | — | US | disclosed |
| EP-1452530-A1 | AZOLE COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2004-09-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065196-A1 | Azole compound and medicinal use thereof | PTPN7, PTPN1, PTPN5 | NPC1 1217/4885RAB9A 1736/4885CHEK1 3803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.