Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PHGDH | O43175 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.30 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.30 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2201981 | 0.74 | IGF1R (0.36) | MEN1KMT2AADRA2BLMNAAR | |
| SCHEMBL12430974 | 0.68 | AURKA (0.44) | MEN1KMT2A | |
| SCHEMBL2203605 | 0.68 | LMNA (0.35) | MEN1KMT2AADRA2BLMNAAR | |
| SCHEMBL12597084 | 0.67 | TAAR1 (0.44) | MEN1KMT2AADRA2BLMNASMN1; SMN2 | |
| SCHEMBL7018616 | 0.63 | ALDH1A1 (0.40) | MEN1KMT2ASMN1; SMN2POLBNPC1 | |
| SCHEMBL2205316 | 0.63 | HTR2C (0.39) | LMNA | |
| SCHEMBL4997567 | 0.62 | TAAR1 (0.43) | MEN1KMT2ALMNAARSMN1; SMN2 | |
| SCHEMBL1182811 | 0.61 | TAAR1 (0.40) | MEN1KMT2ALMNAARSMN1; SMN2 | |
| SCHEMBL18462099 | 0.60 | TAAR1 (0.58) | KMT2ALMNAARSMN1; SMN2POLB | |
| SCHEMBL2285469 | 0.59 | NR4A2 (0.44) | MEN1KMT2AADRA2BPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355905-B1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2007-02-21 | — | — | EP | disclosed |