Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 8/20 | 0.46 |
| ▸ | TNKS | O95271 | 2/20 | 0.46 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.46 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FER | P16591 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5586294 | 1.00 | TNKS2 (0.46) | TNKS2TNKSPARP3MGAT2PDGFRA | |
| SCHEMBL5063241 | 0.83 | MGAT2 (0.56) | TNKS2TNKSPARP3MGAT2PDGFRA | |
| SCHEMBL8267141 | 0.80 | PDGFRA (0.47) | TNKS2MGAT2PDGFRAFERLTK | |
| SCHEMBL9054730 | 0.77 | GFER (0.52) | TNKS2MGAT2PDGFRAFERLTK | |
| SCHEMBL8871785 | 0.77 | GFER (0.52) | TNKS2MGAT2PDGFRAFERLTK | |
| SCHEMBL8871789 | 0.77 | GFER (0.52) | TNKS2MGAT2PDGFRAFERLTK | |
| SCHEMBL17444761 | 0.76 | ALDH1A1 (0.55) | TNKS2PDGFRAFERLTKCDK8 | |
| SCHEMBL14454673 | 0.76 | ALDH1A1 (0.55) | TNKS2PDGFRAFERLTKCDK8 | |
| SCHEMBL14454672 | 0.75 | HSD17B10 (0.64) | PDGFRAFERLTKCDK8ACVR1 | |
| SCHEMBL17061471 | 0.74 | HSD17B10 (0.52) | KDM4EALDH1A1HPGDSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070155730-A1 | Benzodiazepine And Benzopiperazine Analog Inhibitors Of Histone Deacetylase | METHYLGENE, INC. (CA) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155730-A1 | Benzodiazepine And Benzopiperazine Analog Inhibitors Of Histone Deacetylase | HDAC5, HDAC4, HDAC3 | TNKS2 2488/4885TNKS 3196/4885PARP3 1162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.