⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12160657 | 0.87 | ALDH1A1 (0.33) | — | |
| SCHEMBL466044 | 0.87 | LMNA (0.32) | — | |
| SCHEMBL7323509 | 0.87 | LMNA (0.32) | — | |
| Hydrochloric Acid SCHEMBL7322025 | 0.84 | LMNA (0.35) | — | |
| Hydrochloric Acid SCHEMBL7318699 | 0.82 | LMNA (0.33) | — | |
| SCHEMBL4096134 | 0.80 | ESR1 (0.38) | — | |
| SCHEMBL658128 | 0.80 | ESR1 (0.38) | — | |
| SCHEMBL635664 | 0.80 | ESR1 (0.38) | — | |
| SCHEMBL22421189 | 0.79 | — | — | |
| SCHEMBL11509572 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265096-A1 | APOL1 INHIBITORS AND METHODS OF USE | HERCULES CAPITAL, INC., AS AGENT | 2023-08-24 | — | — | US | disclosed |
| US-8293207-B2 | Radiometal-labeled amino acid analogs, imaging and therapeutic agents incorporating the same, and methods using the same | ZAVARZIN VALERY (US) | 2012-10-23 | — | — | US | disclosed |
| WO-2012065022-A2 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-05-18 | — | — | WO | disclosed |
| CN-101076519-B | Amide compound and thrombopoietin receptor activator | NISSAN CHEMICAL IND LTD | 2011-07-20 | — | — | CN | disclosed |
| CN-101076519-A | Amide compound and thrombopoietin receptor activator | NISSAN CHEMICAL IND LTD (JP) | 2007-11-21 | — | — | CN | disclosed |