SCHEMBL5586374

SCHEMBL5586374

CCC1(CCN)CCCC1

nearest known ligand 0.32

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
CYP1A2 P05177 1/20 0.32
TSHR P16473 1/20 0.32
BLM P54132 1/20 0.32
CACNA2D1 P54289 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14088892 0.95
SCHEMBL15830656 0.89
SCHEMBL9209118 0.85 GRIN2D (0.32) USP2ALDH1A1LMNACYP1A2TSHR
SCHEMBL16985068 0.82 USP2 (0.31) USP2ALDH1A1LMNACYP1A2TSHR
SCHEMBL158419 0.80 USP2 (0.41) USP2ALDH1A1LMNACYP1A2TSHR
SCHEMBL15830654 0.80 USP2 (0.34) USP2ALDH1A1LMNACYP1A2TSHR
SCHEMBL16547437 0.78
SCHEMBL19622331 0.78
SCHEMBL76375 0.78 USP2 (0.44) USP2ALDH1A1LMNACYP1A2TSHR
SCHEMBL9968719 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023240024-A1 SULFAMIDE DERIVATIVES AS CYCLIN-DEPENDENT KINASE 2 INHIBITORS NIKANG THERAPEUTICS, INC. (US) 2023-12-14 WO disclosed
US-20210219885-A1 SENSOR ARRAY SYSTEMS AND METHODS FOR DETECTING MULTIPLE ANALYTES ABBOTT DIABETES CARE INC. 2021-07-22 US disclosed
US-9550793-B2 Spirocyclic compounds, compositions and medicinal applications thereof ADVINUS THERAPEUTICS LIMITED (IN) 2017-01-24 US disclosed
EP-2707372-B1 SPIRO-OXINDOLE MDM2 ANTAGONISTS UNIV MICHIGAN REGENTS (US) 2016-12-21 EP disclosed
US-9365499-B2 9-aminomethyl substituted tetracycline compounds KBP BIOSCIENCES CO., LTD. (CN) 2016-06-14 US disclosed
US-9302120-B2 Spiro-oxindole MDM2 antagonists THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2016-04-05 US disclosed
US-20150218187-A1 SPIROCYCLIC COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF IMPETIS BIOSCIENCES LTD. (IN) 2015-08-06 US disclosed
US-9079913-B2 Spiro-oxindole MDM2 antagonists THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2015-07-14 US disclosed
US-9079913-B2 Spiro-oxindole MDM2 antagonists THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2015-07-14 US disclosed
US-20140378680-A1 SPIRO-OXINDOLE MDM2 ANTAGONISTS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2014-12-25 US disclosed
US-8518984-B2 Spiro-oxindole MDM2 antagonists THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2013-08-27 US disclosed
US-8518984-B2 Spiro-oxindole MDM2 antagonists THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2013-08-27 US disclosed
WO-2012155066-A2 SPIRO-OXINDOLE MDM2 ANTAGONISTS WANG SHAOMENG (US) 2012-11-15 WO disclosed
WO-2012065022-A2 SPIRO-OXINDOLE MDM2 ANTAGONISTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2012-05-18 WO disclosed
US-20120122947-A1 SPIRO-OXINDOLE MDM2 ANTAGONISTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2012-05-17 US disclosed
US-20120122947-A1 SPIRO-OXINDOLE MDM2 ANTAGONISTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2012-05-17 US disclosed
WO-2011127058-A2 BIOMARKERS FOR MDM2 INHIBITORS FOR USE IN TREATING DISEASE THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2011-10-13 WO disclosed
WO-2011060049-A2 SPIRO-OXINDOLE MDM2 ANTAGONISTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2011-05-19 WO disclosed
US-20110112052-A1 SPIRO-OXINDOLE MDM2 ANTAGONISTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2011-05-12 US disclosed
US-20110112052-A1 SPIRO-OXINDOLE MDM2 ANTAGONISTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2011-05-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150218187-A1 SPIROCYCLIC COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF DGAT1, DGAT2, CPT1A USP2 4437/4885ALDH1A1 307/4885LMNA 1182/4885
US-20140378680-A1 SPIRO-OXINDOLE MDM2 ANTAGONISTS TP53, MDM2, TP53BP1 USP2 1933/4885ALDH1A1 1498/4885LMNA 2384/4885
US-20110112052-A1 SPIRO-OXINDOLE MDM2 ANTAGONISTS TP53, MDM2, TP53BP1 USP2 1933/4885ALDH1A1 1498/4885LMNA 2384/4885
US-20120122947-A1 SPIRO-OXINDOLE MDM2 ANTAGONISTS TP53, MDM2, TP53BP1 USP2 1933/4885ALDH1A1 1498/4885LMNA 2384/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.