Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2480486 | 0.89 | PDE4B (0.68) | PDE4B | |
| SCHEMBL2479181 | 0.88 | PDE4B (0.71) | PDE4B | |
| SCHEMBL5590656 | 0.86 | PDE4B (0.53) | PDE4B | |
| SCHEMBL1275327 | 0.81 | PDE4B (0.66) | PDE4B | |
| SCHEMBL2481386 | 0.81 | PDE4B (0.59) | PDE4B | |
| SCHEMBL1276200 | 0.80 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4945330 | 0.79 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4948205 | 0.78 | PDE4B (0.55) | PDE4BMAPTPDE4APDE4CPDE4D | |
| SCHEMBL1275591 | 0.77 | PDE4B (0.63) | PDE4B | |
| SCHEMBL1276199 | 0.77 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007501264-A | — | — | 2007-01-25 | — | — | JP | claimed |
| EP-1633748-A1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-15 | — | — | EP | claimed |
| WO-2004103998-A1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-12-02 | — | — | WO | claimed |