SCHEMBL5590839

SCHEMBL5590839

COC(=O)C(C)N1C(=O)CCC1=O

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC1A2 P43004 2/20 0.45
PHGDH O43175 1/20 0.40
RAB9A P51151 2/20 0.39
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39
RECQL P46063 2/20 0.38
KMT2A Q03164 2/20 0.37
ATM Q13315 1/20 0.37
THRB P10828 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
CA14 Q9ULX7 2/20 0.35
ESR1 P03372 1/20 0.35
ESR2 Q92731 1/20 0.35
CA12 O43570 1/20 0.35
NPC1 O15118 1/20 0.35
MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30327623 0.82 SLC1A2 (0.41) SLC1A2ALDH1A1LMNAKMT2AATM
SCHEMBL28231228 0.80 SLC1A2 (0.40) SLC1A2ALDH1A1KMT2AATMMEN1
SCHEMBL4522866 0.80 SLC1A2 (0.40) SLC1A2ALDH1A1KMT2AATMMEN1
SCHEMBL19031828 0.77 SLC1A2 (0.41) SLC1A2ALDH1A1KMT2AATMMEN1
SCHEMBL7259853 0.76 SLC1A2 (0.40) SLC1A2ALDH1A1KMT2AATM
SCHEMBL1564214 0.76 KMT2A (0.53) SLC1A2ALDH1A1KMT2AATMMEN1
SCHEMBL18020563 0.76 SLC1A2 (0.45) SLC1A2ALDH1A1LMNAKMT2AATM
SCHEMBL57078 0.76 KMT2A (0.53) SLC1A2ALDH1A1KMT2AATMMEN1
SCHEMBL5165443 0.75 RECQL (0.41) PHGDHRAB9AALDH1A1LMNARECQL
SCHEMBL15511368 0.75 CA1 (0.41) SLC1A2ALDH1A1LMNAKMT2AATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114364393-A Methods of treatment using G-CSF protein complexes 光谱制药有限公司 2022-04-15 CN claimed
US-20200230253-A1 CONJUGATE OF IDURONATE-2-SULFATASE HANMl PHARM. CO., LTD. (KR) 2020-07-23 US claimed
CN-111433221-A Long-acting conjugates of glucagon-like peptide-2 (G L P-2) derivatives 韩美药品株式会社 2020-07-17 CN claimed
EP-2963055-B1 SITE-SPECIFIC INSULIN CONJUGATE HANMI PHARM IND CO LTD (KR) 2019-05-15 EP claimed
US-20160000931-A1 SITE-SPECIFIC INSULIN CONJUGATE HANMI PHARM. CO., LTD. (KR) 2016-01-07 US claimed
EP-2963055-A1 SITE-SPECIFIC INSULIN CONJUGATE Hanmi Pharm. Co., Ltd. (KR) 2016-01-06 EP claimed
CN-110536899-B Insulin analogue complex with reduced affinity for insulin receptor and uses thereof 韩美药品株式会社 2023-12-12 CN disclosed
CN-117157094-A Pharmaceutical composition for preventing or treating chronic kidney disease comprising glucagon derivative 韩美药品株式会社 2023-12-01 CN disclosed
US-20230330184-A1 METHODS OF TREATING NEUTORPENIA USING G-CSF PROTEIN COMPLEX SPECTRUM PHARMACEUTICALS INC. (US) 2023-10-19 US disclosed
CN-116847868-A Pharmaceutical composition comprising GIP derivative or long-acting conjugate thereof for preventing or treating pulmonary diseases 韩美药品株式会社 2023-10-03 CN disclosed
US-20230270822-A1 NOVEL METHODS OF TREATING NEUTORPENIA USING G-CSF PROTEIN COMPLEX SPECTRUM PHARMACEUTICALS INC. (US) 2023-08-31 US disclosed
CN-116600831-A Triple agonists or conjugates thereof active on all of glucagon, GLP-1 and GLP receptors for the treatment of neurodegenerative diseases 韩美药品株式会社 2023-08-15 CN disclosed
CN-116528885-A Pharmaceutical composition for preventing or treating vasculitis comprising glucagon/GLP-1/GIP triple agonist or long-acting conjugate thereof 韩美药品株式会社 2023-08-01 CN disclosed
CN-111433221-A Long-acting conjugates of glucagon-like peptide-2 (G L P-2) derivatives 韩美药品株式会社 2020-07-17 CN disclosed
EP-2963055-B1 SITE-SPECIFIC INSULIN CONJUGATE HANMI PHARM IND CO LTD (KR) 2019-05-15 EP disclosed
US-20160000931-A1 SITE-SPECIFIC INSULIN CONJUGATE HANMI PHARM. CO., LTD. (KR) 2016-01-07 US disclosed
EP-2963055-A1 SITE-SPECIFIC INSULIN CONJUGATE Hanmi Pharm. Co., Ltd. (KR) 2016-01-06 EP disclosed
EP-1861125-A2 CONJUGATES OF AN HGH MOIETY AND PEG DERIVATIVES Nektar Therapeutics Al, Corporation (US) 2007-12-05 EP disclosed
US-20060233740-A1 Conjugates of an hGH moiety and a polymer NEKTAR THERAPEUTICS 2006-10-19 US disclosed
WO-2006102659-A2 CONJUGATES OF AN hGH MOIETY AND A POLYMER NEKTAR THERAPEUTICS AL, CORPORATION (US) 2006-09-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060233740-A1 Conjugates of an hGH moiety and a polymer GGH, NGLY1, FOLH1 SLC1A2 722/4885PHGDH 39/4885RAB9A 3601/4885
US-20200230253-A1 CONJUGATE OF IDURONATE-2-SULFATASE IDUA, FCGR2A, CNDP2 SLC1A2 1274/4885PHGDH 449/4885RAB9A 4380/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.