Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 9/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | NEK2 | P51955 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5591238 | 0.92 | MPL (0.60) | MPLP2RY12ALDH1A1HSD17B10USP2 | |
| SCHEMBL5591086 | 0.92 | MPL (0.58) | MPLNPC1RAB9AP2RY12ALDH1A1 | |
| SCHEMBL5609208 | 0.91 | MPL (0.60) | MPLP2RY12 | |
| SCHEMBL5591060 | 0.90 | MPL (0.68) | MPLNPC1RAB9ANEK2 | |
| SCHEMBL5590857 | 0.88 | MPL (0.61) | MPL | |
| SCHEMBL5591245 | 0.87 | MPL (0.68) | MPLNPC1RAB9AP2RY12MEN1 | |
| SCHEMBL5591371 | 0.87 | MPL (0.63) | MPL | |
| SCHEMBL5590953 | 0.86 | MPL (0.67) | MPL | |
| SCHEMBL5591424 | 0.84 | MPL (0.52) | MPLNPC1RAB9AP2RY12MAPT | |
| SCHEMBL5026777 | 0.84 | MPL (0.55) | MPLRAB9AP2RY12MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007004038-A1 | AMINOTHIAZOLE DERIVATIVES AS AGONISTS OF THE THROMBOPOIETIN RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-01-11 | — | — | WO | disclosed |