Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 19/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5591040 | 0.91 | MPL (0.62) | MPL | |
| SCHEMBL5591371 | 0.90 | MPL (0.63) | MPL | |
| SCHEMBL5591365 | 0.89 | MPL (0.72) | MPL | |
| SCHEMBL5591245 | 0.88 | MPL (0.68) | MPLNPC1RAB9A | |
| SCHEMBL5590953 | 0.87 | MPL (0.67) | MPL | |
| SCHEMBL5609208 | 0.86 | MPL (0.60) | MPL | |
| SCHEMBL5597900 | 0.85 | MPL (0.81) | MPL | |
| SCHEMBL5591424 | 0.84 | MPL (0.52) | MPLNPC1MAPTRAB9A | |
| SCHEMBL5590857 | 0.84 | MPL (0.61) | MPL | |
| SCHEMBL5026777 | 0.84 | MPL (0.55) | MPLMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007004038-A1 | AMINOTHIAZOLE DERIVATIVES AS AGONISTS OF THE THROMBOPOIETIN RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-01-11 | — | — | WO | claimed |
| WO-2007004038-A1 | AMINOTHIAZOLE DERIVATIVES AS AGONISTS OF THE THROMBOPOIETIN RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-01-11 | — | — | WO | disclosed |