SCHEMBL5591118

SCHEMBL5591118

Cc1cc(-c2csc(NC(=O)c3cnc(N4CCC(C(=O)O)CC4)c(Cl)c3)n2)ccc1Cl

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MPL P40238 19/20 0.74
ABL1 P00519 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5591002 0.93 MPL (0.81) MPL
SCHEMBL5590857 0.90 MPL (0.61) MPLABL1
SCHEMBL5591096 0.89 MPL (0.74) MPL
SCHEMBL5591212 0.89 MPL (0.84) MPL
SCHEMBL5591104 0.88 MPL (0.79) MPL
SCHEMBL5590820 0.88 MPL (0.71) MPL
SCHEMBL5590838 0.88 MPL (0.65) MPL
SCHEMBL5591090 0.88 MPL (0.75) MPL
SCHEMBL5590976 0.86 MPL (0.66) MPL
SCHEMBL5591060 0.86 MPL (0.68) MPL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007004038-A1 AMINOTHIAZOLE DERIVATIVES AS AGONISTS OF THE THROMBOPOIETIN RECEPTOR PFIZER PRODUCTS INC. (US) 2007-01-11 WO claimed