Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cholesterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 4/20 | 0.71 |
| ▸ | RORC | P51449 | 4/20 | 0.71 |
| ▸ | OSBP2 | Q969R2 | 2/20 | 0.71 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.71 |
| ▸ | USP2 | O75604 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.71 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.62 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.62 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.62 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.62 |
| ▸ | POLA1 | P09884 | 1/20 | 0.61 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.59 |
| ▸ | CRYAB | P02511 | 1/20 | 0.59 |
| ▸ | HMGCR | P04035 | 1/20 | 0.59 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.59 |
| ▸ | ITGAV | P06756 | 1/20 | 0.59 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.59 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.58 |
| ▸ | DHCR24 | Q15392 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholesterol SCHEMBL29033213 | 0.92 | OSBP (0.82) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL1296896 | 0.92 | OSBP (0.82) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL21644732 | 0.91 | OSBP (0.78) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL21644734 | 0.91 | OSBP (0.78) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL9186853 | 0.89 | OSBP (0.77) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL246637 | 0.89 | OSBP (0.79) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL246634 | 0.87 | OSBP (0.79) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL162526 | 0.87 | OSBP (0.82) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL29065777 | 0.87 | OSBP (0.82) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL28035647 | 0.87 | OSBP (0.82) | OSBPRORCOSBP2CYP46A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3826025-A2 | PHARMACEUTICAL PACKAGING AND METHOD FOR DELIVERY OF SAME | Daya Medicals, Inc. (US) | 2021-05-26 | — | — | EP | disclosed |
| US-20070112593-A1 | Selection system, dispensing system and treatment with a one-a-day combination pill for hypertension, hypercholesterolemia, hypertriglyceridemia and anti-platelet treatment | RXCERA PHARMACEUTICAL, INC. | 2007-05-17 | — | — | US | disclosed |