Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 14/20 | 0.66 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5590976 | 0.85 | MPL (0.66) | MPL | |
| SCHEMBL5591267 | 0.82 | MPL (0.56) | MPLNPC1MEN1RAB9AKMT2A | |
| SCHEMBL5591050 | 0.82 | MPL (0.57) | MPLNPC1MEN1RAB9AKMT2A | |
| SCHEMBL5590838 | 0.81 | MPL (0.65) | MPL | |
| SCHEMBL5591118 | 0.80 | MPL (0.74) | MPLABL1 | |
| SCHEMBL5591145 | 0.80 | MPL (1.00) | MPL | |
| SCHEMBL5591002 | 0.79 | MPL (0.81) | MPL | |
| SCHEMBL5591168 | 0.78 | MPL (0.81) | MPL | |
| SCHEMBL5590857 | 0.74 | MPL (0.61) | MPLABL1 | |
| SCHEMBL5591212 | 0.74 | MPL (0.84) | MPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007004038-A1 | AMINOTHIAZOLE DERIVATIVES AS AGONISTS OF THE THROMBOPOIETIN RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-01-11 | — | — | WO | claimed |
| WO-2007004038-A1 | AMINOTHIAZOLE DERIVATIVES AS AGONISTS OF THE THROMBOPOIETIN RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-01-11 | — | — | WO | disclosed |