Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 10/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598072 | 0.86 | PLAU (0.48) | PLAUNAMPTMAPTTDP1NPSR1 | |
| SCHEMBL5591785 | 0.81 | PLAU (0.47) | PLAUMAPTTDP1NPSR1KDM4E | |
| SCHEMBL8235456 | 0.80 | PLAU (0.47) | PLAUNAMPTMAPTTDP1NPSR1 | |
| SCHEMBL5591560 | 0.78 | PLAU (0.44) | PLAUNAMPTMAPTTDP1NPSR1 | |
| SCHEMBL2487696 | 0.76 | CA12 (0.48) | MAPTKDM4EGLAGAASLC5A1 | |
| SCHEMBL5591556 | 0.76 | PLAU (0.42) | PLAUMAPTTDP1NPSR1KDM4E | |
| SCHEMBL31307120 | 0.76 | IDO1 (0.44) | NAMPTMAPTTDP1 | |
| SCHEMBL12639204 | 0.76 | CYP17A1 (0.55) | NAMPTKMT2AMEN1 | |
| SCHEMBL8235752 | 0.75 | MAPT (0.41) | PLAUNAMPTMAPTTDP1NPSR1 | |
| SCHEMBL8229818 | 0.75 | HDAC1 (0.47) | PLAUNAMPTMAPTKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007072041-A1 | THERAPEUTIC COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |