Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8230030 | 0.86 | PLAU (0.53) | PLAUKMT2AHDAC1HDAC6 | |
| SCHEMBL8235456 | 0.85 | PLAU (0.47) | MAPTTDP1NPSR1KDM4ECA1 | |
| SCHEMBL5598072 | 0.80 | PLAU (0.48) | MAPTTDP1NPSR1XBP1GPR55 | |
| SCHEMBL8229818 | 0.79 | HDAC1 (0.47) | MAPTKDM4ENAMPTPLAUKMT2A | |
| SCHEMBL5591785 | 0.75 | PLAU (0.47) | MAPTTDP1NPSR1KDM4ECA1 | |
| SCHEMBL5591557 | 0.75 | PLAU (0.43) | MAPTTDP1NPSR1XBP1GPR55 | |
| SCHEMBL5591617 | 0.74 | PLAU (0.46) | KDM4ECA1CA2PLAU | |
| SCHEMBL5591687 | 0.74 | CA12 (0.42) | KDM4ECA1CA2 | |
| SCHEMBL5591556 | 0.72 | PLAU (0.42) | MAPTTDP1NPSR1KDM4ECA1 | |
| SCHEMBL5591560 | 0.72 | PLAU (0.44) | MAPTTDP1NPSR1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007072041-A1 | THERAPEUTIC COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |