Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 6/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598072 | 0.85 | PLAU (0.48) | PLAUTAS1R3TAS1R1TAS1R2CA12 | |
| SCHEMBL8229818 | 0.85 | HDAC1 (0.47) | PLAUMAPTKDM4EMEN1KMT2A | |
| SCHEMBL8235752 | 0.85 | MAPT (0.41) | PLAUCA1CA2MAPTKDM4E | |
| SCHEMBL8235458 | 0.84 | PLAU (0.65) | PLAUTAS1R3TAS1R1TAS1R2NPC1 | |
| SCHEMBL5591785 | 0.81 | PLAU (0.47) | PLAUTAS1R3TAS1R1TAS1R2CA12 | |
| SCHEMBL5591557 | 0.80 | PLAU (0.43) | PLAUTAS1R3TAS1R1TAS1R2MAPT | |
| SCHEMBL5591617 | 0.80 | PLAU (0.46) | PLAUCA12CA1CA2CA9 | |
| SCHEMBL5591687 | 0.79 | CA12 (0.42) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL5591560 | 0.77 | PLAU (0.44) | PLAUTAS1R3TAS1R1TAS1R2CA12 | |
| SCHEMBL8230026 | 0.76 | PLAU (0.77) | PLAUTAS1R3TAS1R1TAS1R2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007072041-A1 | THERAPEUTIC COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |