Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014779 | 0.86 | SIGMAR1 (0.59) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL6408859 | 0.85 | SIGMAR1 (0.47) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL6414709 | 0.85 | SIGMAR1 (0.48) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL5255706 | 0.85 | SIGMAR1 (0.48) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL6409136 | 0.85 | SIGMAR1 (0.48) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL6410306 | 0.85 | SIGMAR1 (0.48) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL4833925 | 0.84 | KMT2A (0.46) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL4833327 | 0.83 | KMT2A (0.45) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL4836434 | 0.83 | SIGMAR1 (0.43) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL14520045 | 0.83 | CCR5 (0.46) | SIGMAR1DRD2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007065256-A1 | NOVEL SPIROPIPERIDINE COMPOUNDS AND METHODS FOR THE MODULATION OF CHEMOKINE RECEPTOR ACTIVITY | VIROCHEM PHARMA INC. (CA) | 2007-06-14 | — | — | WO | claimed |
| WO-2007065256-A1 | NOVEL SPIROPIPERIDINE COMPOUNDS AND METHODS FOR THE MODULATION OF CHEMOKINE RECEPTOR ACTIVITY | VIROCHEM PHARMA INC. (CA) | 2007-06-14 | — | — | WO | disclosed |