Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | F10 | P00742 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 8/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | HRH2 | P25021 | 3/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5836154 | 0.84 | MEN1 (0.53) | MEN1KMT2ANPSR1SMN1; SMN2NPC1 | |
| SCHEMBL5592314 | 0.81 | MEN1 (0.51) | MEN1KMT2ANPSR1F10SMN1; SMN2 | |
| SCHEMBL5592160 | 0.81 | USP2 (0.42) | MEN1KMT2ANPSR1F10SMN1; SMN2 | |
| SCHEMBL6323472 | 0.81 | MEN1 (0.48) | MEN1KMT2ANPSR1F10SMN1; SMN2 | |
| SCHEMBL1949475 | 0.81 | HPGD (0.56) | MEN1KMT2ANPSR1F10SMN1; SMN2 | |
| SCHEMBL3767269 | 0.79 | TMEM97 (0.47) | MEN1KMT2ANPSR1SMN1; SMN2NPC1 | |
| SCHEMBL5592397 | 0.78 | TMEM97 (0.47) | MEN1KMT2ANPSR1F10SMN1; SMN2 | |
| SCHEMBL4691214 | 0.77 | HRH3 (0.52) | SMN1; SMN2NPC1RAB9ACYP2C19HRH1 | |
| SCHEMBL5592390 | 0.76 | TMEM97 (0.46) | MEN1KMT2ANPSR1F10SMN1; SMN2 | |
| SCHEMBL19960792 | 0.75 | SMN1; SMN2 (0.45) | MEN1KMT2ANPSR1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007057742-A2 | NOVEL PIPERAZINONE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2007-05-24 | — | — | WO | disclosed |