Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.75 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.75 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.75 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.75 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.75 |
| ▸ | P2RX5 | Q93086 | 2/20 | 0.75 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | CASP1 | P29466 | 1/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | RAB9A | P51151 | 1/20 | 0.75 |
| ▸ | CASP7 | P55210 | 1/20 | 0.75 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.64 |
| ▸ | P2RY13 | Q9BPV8 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13624677 | 0.86 | MAPT (1.00) | MAPTTDP1P2RY1P2RX2P2RX3 | |
| SCHEMBL31236767 | 0.86 | MAPT (1.00) | MAPTTDP1P2RY1P2RX2P2RX3 | |
| SCHEMBL7196930 | 0.86 | MAPT (1.00) | MAPTTDP1P2RY1P2RX2P2RX3 | |
| SCHEMBL29357199 | 0.86 | MAPT (1.00) | MAPTTDP1P2RY1P2RX2P2RX3 | |
| SCHEMBL5287746 | 0.86 | MAPT (1.00) | MAPTTDP1P2RY1P2RX2P2RX3 | |
| SCHEMBL7196945 | 0.86 | MAPT (1.00) | MAPTTDP1P2RY1P2RX2P2RX3 | |
| Isoppads SCHEMBL14702227 | 0.82 | MAPT (1.00) | MAPTTDP1P2RY1P2RX2P2RX3 | |
| Isoppads SCHEMBL29494952 | 0.82 | MAPT (1.00) | MAPTTDP1P2RY1P2RX2P2RX3 | |
| SCHEMBL15866621 | 0.80 | P2RX2 (1.00) | MAPTTDP1P2RY1P2RX2P2RX3 | |
| SCHEMBL29374112 | 0.76 | MAPT (0.78) | MAPTTDP1P2RY1P2RX2P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007042776-A1 | MODULATORS OF THE PURINERGIC SIGNALLING PATHWAY FOR TREATING SODIUM HOMEOSTATSIS, HYPERTENSION AND ALDOSTERONISM | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2007-04-19 | — | — | WO | claimed |
| WO-2007042776-A1 | MODULATORS OF THE PURINERGIC SIGNALLING PATHWAY FOR TREATING SODIUM HOMEOSTATSIS, HYPERTENSION AND ALDOSTERONISM | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |