SCHEMBL5593247

SCHEMBL5593247

Cc1cc(F)c(-c2c(C#N)nc3ncnn3c2N2CCCC2C)cc1F

nearest known ligand 0.46

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
EGLN2 Q96KS0 7/20 0.46
PDE2A O00408 11/20 0.39
LRRK2 Q5S007 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5593080 0.97 EGLN2 (0.43) EGLN2PDE2ALRRK2
SCHEMBL5593131 0.88 EGLN2 (0.44) EGLN2PDE2ALRRK2
SCHEMBL5593488 0.88 PDE2A (0.41) EGLN2PDE2A
SCHEMBL5593341 0.86 EGLN2 (0.41) EGLN2PDE2A
SCHEMBL5593422 0.86 EGLN2 (0.41) EGLN2PDE2A
SCHEMBL5593283 0.86 PDE2A (0.40) EGLN2PDE2A
SCHEMBL5593381 0.85 EGLN2 (0.41) EGLN2PDE2ALRRK2
SCHEMBL5593226 0.85 PDE2A (0.39) EGLN2PDE2A
SCHEMBL5593345 0.84 EGLN2 (0.42) EGLN2PDE2A
SCHEMBL5593567 0.84 PDE2A (0.39) EGLN2PDE2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007099092-A1 SUBSTITUTED 6-PHENYL-7-AMINO[1,2,4]-TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE FOR CONTROLLING PATHOGENIC FUNGI BASF SE (DE) 2007-09-07 WO claimed
WO-2007099092-A1 SUBSTITUTED 6-PHENYL-7-AMINO[1,2,4]-TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE FOR CONTROLLING PATHOGENIC FUNGI BASF SE (DE) 2007-09-07 WO disclosed