SCHEMBL5593422

SCHEMBL5593422

Cc1cc(F)c(-c2c(C#N)nc3ncnn3c2N2CCC(C)CC2)cc1F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGLN2 Q96KS0 9/20 0.41
ALDH1A1 P00352 3/20 0.39
LMNA P02545 2/20 0.39
TSHR P16473 2/20 0.38
KDM4E B2RXH2 1/20 0.38
MAPT P10636 1/20 0.38
HPGD P15428 1/20 0.38
ALOX15 P16050 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HSD17B10 Q99714 1/20 0.38
GLA P06280 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
RCE1 Q9Y256 1/20 0.35
PDE2A O00408 3/20 0.35
GAA P10253 1/20 0.34
GFER P55789 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
PAX2 Q02962 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5593085 0.95 EGLN2 (0.46) EGLN2ALDH1A1LMNATSHRKDM4E
SCHEMBL5593381 0.90 EGLN2 (0.41) EGLN2ALDH1A1LMNATSHRKDM4E
SCHEMBL5593345 0.89 EGLN2 (0.42) EGLN2ALDH1A1LMNATSHRHPGD
SCHEMBL5593357 0.88 KDM1A (0.41) EGLN2ALDH1A1LMNATSHRKDM4E
SCHEMBL5746793 0.87 EGLN2 (0.43) EGLN2ALDH1A1LMNATSHRKDM4E
SCHEMBL5593344 0.87 LMNA (0.44) EGLN2ALDH1A1LMNATSHRMAPT
SCHEMBL5593247 0.86 EGLN2 (0.46) EGLN2PDE2A
SCHEMBL5593080 0.85 EGLN2 (0.43) EGLN2ALDH1A1MAPTMEN1KMT2A
SCHEMBL5593427 0.85 ALDH1A1 (0.41) EGLN2ALDH1A1LMNATSHRMAPT
SCHEMBL5462930 0.84 EGLN2 (0.44) EGLN2ALDH1A1LMNATSHRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007099092-A1 SUBSTITUTED 6-PHENYL-7-AMINO[1,2,4]-TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE FOR CONTROLLING PATHOGENIC FUNGI BASF SE (DE) 2007-09-07 WO claimed
WO-2007099092-A1 SUBSTITUTED 6-PHENYL-7-AMINO[1,2,4]-TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE FOR CONTROLLING PATHOGENIC FUNGI BASF SE (DE) 2007-09-07 WO disclosed