Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8259644 | 0.81 | CHRM3 (0.44) | CHRM3SLC6A3SLC6A2SLC6A4ACHE | |
| Hydrochloric Acid SCHEMBL3105434 | 0.79 | CHRM3 (0.43) | CHRM3SLC6A3SLC6A2SLC6A4ACHE | |
| SCHEMBL19549307 | 0.79 | CHRM3 (0.43) | CHRM3SLC6A3SLC6A2SLC6A4ACHE | |
| SCHEMBL12652755 | 0.78 | TSHR (0.36) | SLC6A3SLC6A2SLC6A4ADORA1TSHR | |
| SCHEMBL18756753 | 0.77 | CHRM3 (0.45) | CHRM3SLC6A3SLC6A2SLC6A4ACHE | |
| SCHEMBL9491024 | 0.76 | PNMT (0.39) | SLC6A3SLC6A2SLC6A4ADORA1 | |
| SCHEMBL28924631 | 0.76 | CHRM3 (0.43) | CHRM3SLC6A3SLC6A2SLC6A4ACHE | |
| SCHEMBL22717377 | 0.76 | CHRM3 (0.43) | CHRM3SLC6A3SLC6A2SLC6A4ACHE | |
| SCHEMBL2490865 | 0.74 | — | — | |
| SCHEMBL16579387 | 0.72 | CHRM3 (0.35) | CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2354134-B1 | 2H-CHROMENE DERIVATIVES AS STIMULATORS OF SPHINGOSINE 1-PHOSPHATE RECEPTOR | ASTELLAS PHARMA INC (JP) | 2016-02-24 | — | — | EP | disclosed |
| US-20120178735-A1 | 2H-CHROMENE COMPOUND AND DERIVATIVE THEREOF | ASTELLAS PHARMA INC. (JP) | 2012-07-12 | — | — | US | disclosed |
| US-20120178735-A1 | 2H-CHROMENE COMPOUND AND DERIVATIVE THEREOF | ASTELLAS PHARMA INC. (JP) | 2012-07-12 | — | — | US | disclosed |
| US-8193378-B2 | 2H-chromene compound and derivative thereof | ASTELLAS PHARMA INC. (JP) | 2012-06-05 | — | — | US | disclosed |
| US-8193378-B2 | 2H-chromene compound and derivative thereof | ASTELLAS PHARMA INC. (JP) | 2012-06-05 | — | — | US | disclosed |
| US-20110230463-A1 | 2H-CHROMENE COMPOUND AND DERIVATIVE THEREOF | ASTELLAS PHARMA INC. (JP) | 2011-09-22 | — | — | US | disclosed |
| US-20110230463-A1 | 2H-CHROMENE COMPOUND AND DERIVATIVE THEREOF | ASTELLAS PHARMA INC. (JP) | 2011-09-22 | — | — | US | disclosed |
| EP-2354134-A1 | 2H-CHROMENE COMPOUND AND DERIVATIVE THEREOF | Astellas Pharma Inc. (JP) | 2011-08-10 | — | — | EP | disclosed |
| WO-2010064707-A1 | 2H-CHROMENE COMPOUND AND DERIVATIVE THEREOF | アステラス製薬株式会社 (JP) | 2010-06-10 | — | — | WO | disclosed |
| WO-2007117558-A2 | ANTIOXIDANTS AND METHODS OF THEIR USE | MICHIGAN STATE UNIVERSITY (US) | 2007-10-18 | — | — | WO | disclosed |
| WO-1995011678-A9 | USE OF NICOTINE SUBSTITUTES FOR THE TREATMENT OF NICOTINE WITHDRAWAL | — | 1995-06-08 | — | — | WO | disclosed |
| EP-0091565-A1 | Process for the manufacture of isoquinoline diones | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-10-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230463-A1 | 2H-CHROMENE COMPOUND AND DERIVATIVE THEREOF | S1PR1, S1PR2, CCR1 | CHRM3 181/4885SLC6A3 3681/4885SLC6A2 2026/4885 |
| US-20120178735-A1 | 2H-CHROMENE COMPOUND AND DERIVATIVE THEREOF | S1PR1, S1PR2, S1PR4 | CHRM3 309/4885SLC6A3 3979/4885SLC6A2 2801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.