Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.68 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.68 |
| ▸ | CDK2 | P24941 | 8/20 | 0.53 |
| ▸ | TTK | P33981 | 2/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5594175 | 0.91 | AURKA (0.58) | AURKAAURKBCDK2TTKCDK1 | |
| SCHEMBL5593757 | 0.77 | AURKA (0.51) | AURKAAURKBCDK2CDK1CDK4 | |
| SCHEMBL22890624 | 0.73 | LRRK2 (0.74) | — | |
| SCHEMBL22890323 | 0.73 | LRRK2 (0.74) | — | |
| SCHEMBL29643542 | 0.73 | LRRK2 (0.74) | — | |
| SCHEMBL4728731 | 0.70 | CCKBR (0.65) | AURKANAMPTROCK2NPC1RAB9A | |
| SCHEMBL2569400 | 0.69 | TTK (1.00) | AURKAAURKBTTK | |
| SCHEMBL22334934 | 0.69 | NR1H4 (0.68) | AURKAAURKBCDK2CDK1CCNA2 | |
| SCHEMBL12907278 | 0.69 | JAK2 (0.55) | AURKAAURKBCDK2TTKROCK2 | |
| SCHEMBL2556963 | 0.68 | KDM1A (0.72) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058626-A1 | INDAZOLE COMPOUNDS | S*BIO PTE LTD (SG) | 2007-05-24 | — | — | WO | claimed |