Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.75 |
| ▸ | MAPT | P10636 | 9/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 9/20 | 0.75 |
| ▸ | LMNA | P02545 | 5/20 | 0.75 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.75 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.75 |
| ▸ | RELA | Q04206 | 4/20 | 0.75 |
| ▸ | TP53 | P04637 | 4/20 | 0.75 |
| ▸ | GAA | P10253 | 4/20 | 0.75 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.75 |
| ▸ | BRD4 | O60885 | 2/20 | 0.75 |
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.67 |
| ▸ | METAP2 | P50579 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.62 |
| ▸ | HTT | P42858 | 5/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2518179 | 0.90 | KDM4E (0.86) | KDM4EMAPTL3MBTL1LMNANFKB1 | |
| Hydrochloric Acid SCHEMBL5594620 | 0.88 | KDM4E (0.83) | KDM4EMAPTL3MBTL1LMNANFKB1 | |
| SCHEMBL24716091 | 0.87 | KDM4E (0.97) | KDM4EMAPTL3MBTL1LMNANFKB1 | |
| SCHEMBL30626619 | 0.87 | KDM4E (0.97) | KDM4EMAPTL3MBTL1LMNANFKB1 | |
| SCHEMBL5594386 | 0.86 | KDM4E (1.00) | KDM4EMAPTL3MBTL1LMNANFKB1 | |
| SCHEMBL5594566 | 0.86 | KDM4E (0.89) | KDM4EMAPTL3MBTL1LMNANFKB1 | |
| SCHEMBL23714056 | 0.85 | L3MBTL1 (0.59) | KDM4EMAPTL3MBTL1LMNANFKB1 | |
| SCHEMBL17223775 | 0.84 | L3MBTL1 (0.58) | KDM4EMAPTL3MBTL1LMNANFKB1 | |
| SCHEMBL1240789 | 0.84 | L3MBTL1 (0.80) | KDM4EMAPTL3MBTL1LMNANFKB1 | |
| SCHEMBL5594558 | 0.83 | KDM4E (0.75) | KDM4EMAPTL3MBTL1LMNANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189606-B1 | NOVEL IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING IRON CHELATORS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | YEDA RES & DEV (IL) | 2007-08-15 | — | — | EP | claimed |
| US-6855711-B1 | Pharmaceutical compositions comprising iron chelators for the treatment of neurodegenerative disorders and some novel iron chelators | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2005-02-15 | — | — | US | claimed |
| EP-4623914-A1 | USE OF 8-HYDROXYQUINOLINE DERIVATIVE | Jiangsu Yahong Meditech Co., Ltd. (CN) | 2025-10-01 | — | — | EP | disclosed |
| EP-4622962-A1 | SMALL MOLECULAR WEIGHT CHEMICAL COMPOUND TO ANTAGONIZE EPH-EPHRIN TETRAMERIZATION AND INHIBIT BIDIRECTIONAL SIGNALING | The Board of Regents of the University of Texas System (US) | 2025-10-01 | — | — | EP | disclosed |
| CN-120035438-A | Use of 8-hydroxyquinoline derivatives | 江苏亚虹医药科技股份有限公司 | 2025-05-23 | — | — | CN | disclosed |
| US-20240246916-A1 | 7-NITRO-8-HYDROXYQUINOLINE DERIVATIVES, PREPARATION METHOD THEREFORE AND MEDICAL USE THEREOF | JIANGSU YAHONG MEDITECH CO., LTD. (CN) | 2024-07-25 | — | — | US | disclosed |
| WO-2024109684-A1 | USE OF 8-HYDROXYQUINOLINE DERIVATIVE | 江苏亚虹医药科技股份有限公司 | 2024-05-30 | — | — | WO | disclosed |
| CN-118059101-A | Use of 8-hydroxyquinoline derivatives | 江苏亚虹医药科技股份有限公司 | 2024-05-24 | — | — | CN | disclosed |
| WO-2024092083-A1 | SMALL MOLECULAR WEIGHT CHEMICAL COMPOUND TO ANTAGONIZE EPH-EPHRIN TETRAMERIZATION AND INHIBIT BIDIRECTIONAL SIGNALING | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-05-02 | — | — | WO | disclosed |
| WO-2024092083-A1 | SMALL MOLECULAR WEIGHT CHEMICAL COMPOUND TO ANTAGONIZE EPH-EPHRIN TETRAMERIZATION AND INHIBIT BIDIRECTIONAL SIGNALING | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-05-02 | — | — | WO | disclosed |
| EP-4349815-A1 | 7-NITRO-8-HYDROXYQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | Jiangsu Yahong Meditech Co., Ltd. (CN) | 2024-04-10 | — | — | EP | disclosed |
| US-10905682-B2 | Use of mitochondrial iron chelators for treatment of chronic obstructive pulmonary disease | CORNELL UNIVERSITY (US) | 2021-02-02 | — | — | US | disclosed |
| US-20180360815-A1 | USE OF MITOCHONDRIAL IRON CHELATORS FOR TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-12-20 | — | — | US | disclosed |
| EP-3383415-A1 | USE OF MITOCHONDRIAL IRON CHELATORS FOR TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | Cornell University (US) | 2018-10-10 | — | — | EP | disclosed |
| WO-2017096013-A1 | USE OF MITOCHONDRIAL IRON CHELATORS FOR TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | CORNELL UNIVERSITY (US) | 2017-06-08 | — | — | WO | disclosed |
| EP-1189606-B1 | NOVEL IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING IRON CHELATORS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | YEDA RES & DEV (IL) | 2007-08-15 | — | — | EP | disclosed |
| EP-1189606-B1 | NOVEL IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING IRON CHELATORS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | YEDA RES & DEV (IL) | 2007-08-15 | — | — | EP | disclosed |
| US-6855711-B1 | Pharmaceutical compositions comprising iron chelators for the treatment of neurodegenerative disorders and some novel iron chelators | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2005-02-15 | — | — | US | disclosed |
| EP-1189606-A2 | NOVEL IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING IRON CHELATORS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | YEDA RESEARCH AND DEVELOPMENT Co. LTD. (IL) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000074664-A2 | NOVEL IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING IRON CHELATORS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2000-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240246916-A1 | 7-NITRO-8-HYDROXYQUINOLINE DERIVATIVES, PREPARATION METHOD THEREFORE AND MEDICAL USE THEREOF | CYP3A7, UGT1A7, UGT2B7 | KDM4E 2921/4885MAPT 4416/4885L3MBTL1 3845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.