Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL559756 | 0.93 | ADORA2A (0.46) | ADORA2AADORA3ADORA1PIK3CDGRIN2B | |
| SCHEMBL560133 | 0.92 | ADORA2A (0.43) | ADORA2AADORA3ADORA1LIPENPC1 | |
| SCHEMBL559641 | 0.92 | ADORA2A (0.42) | ADORA2AADORA3ADORA1GRIN2BBTK | |
| SCHEMBL559730 | 0.91 | ADORA2A (0.43) | ADORA2ALIPENPC1RAB9A | |
| SCHEMBL559125 | 0.91 | ADORA2A (0.44) | ADORA2AADORA3ADORA1LIPENPC1 | |
| SCHEMBL560397 | 0.89 | CYP1A2 (0.43) | ADORA2ACYP1A2FAAH | |
| SCHEMBL560112 | 0.85 | ADORA2A (0.44) | ADORA2ACYP2C9CYP2C19ADORA3ADORA1 | |
| SCHEMBL559355 | 0.83 | ADORA2A (0.41) | ADORA2ACYP1A2CYP2C9CYP2C19ADORA3 | |
| SCHEMBL559164 | 0.83 | TRPV1 (0.41) | ADORA2APIK3CDBTKLIPENPC1 | |
| SCHEMBL559647 | 0.80 | ADORA2A (0.48) | ADORA2ACYP1A2CYP2C9CYP2C19ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120309774-A1 | SELECTIVE ANTAGONISTS OF A2A ADENOSINE RECEPTORS | ADENOSINE THERAPEUTICS, LLC | 2012-12-06 | — | — | US | disclosed |
| US-20120035192-A1 | SELECTIVE ANTAGONISTS OF A2A ADENOSINE RECEPTORS | ADENOSINE THERAPEUTICS, LLC | 2012-02-09 | — | — | US | disclosed |
| US-7985754-B2 | Selective antagonists of A2A adenosine receptors | TROVIS PHARMACEUTICALS, LLC (US) | 2011-07-26 | — | — | US | disclosed |
| US-20090118309-A1 | Selective antagonists of A2A adenosine receptors | ADENOSINE THERAPEUTICS, LLC | 2009-05-07 | — | — | US | disclosed |
| EP-2041136-A2 | SELECTIVE ANTAGONISTS OF A2A ADENOSINE RECEPTORS | PGXHealth, LLC (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008011007-A2 | SELECTIVE ANTAGONISTS OF A2A ADENOSINE RECEPTORS | PGXHEALTH, LLC (US) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309774-A1 | SELECTIVE ANTAGONISTS OF A2A ADENOSINE RECEPTORS | ADORA2A, ADORA3, ADORA2B | ADORA2A 1/4885CYP1A2 497/4885CYP2C9 981/4885 |
| US-20090118309-A1 | Selective antagonists of A2A adenosine receptors | ADORA2A, ADORA3, ADORA2B | ADORA2A 1/4885CYP1A2 497/4885CYP2C9 981/4885 |
| US-20120035192-A1 | SELECTIVE ANTAGONISTS OF A2A ADENOSINE RECEPTORS | ADORA2A, ADORA3, ADORA2B | ADORA2A 1/4885CYP1A2 497/4885CYP2C9 981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.