Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.61 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6760901 | 0.84 | EPHX2 (0.56) | KMT2AMEN1TRPV1MAPTTP53 | |
| SCHEMBL6764064 | 0.84 | P2RX1 (0.64) | KMT2AMEN1MAPTGAAALDH1A1 | |
| SCHEMBL6820148 | 0.84 | CYP1A2 (0.54) | CYP3A4CYP2C19CYP1A2CYP2D6CHRNA7 | |
| SCHEMBL330643 | 0.82 | TMPRSS4 (0.69) | CYP3A4CYP2C19CYP1A2CYP2D6CHRNA7 | |
| SCHEMBL20472469 | 0.82 | CHRNA7 (0.76) | CYP3A4CYP2C19CYP1A2CHRNA7KMT2A | |
| SCHEMBL29776952 | 0.82 | CHRNA7 (0.76) | CYP3A4CYP2C19CYP1A2CHRNA7KMT2A | |
| SCHEMBL5613115 | 0.81 | CYP1A2 (0.49) | CYP3A4CYP2C19CYP1A2CYP2D6CHRNA7 | |
| SCHEMBL1463349 | 0.81 | GSK3A (0.66) | KMT2AMEN1TRPV1MAPTGAA | |
| SCHEMBL5595253 | 0.81 | CHRNA7 (0.61) | CYP3A4CYP2C19CYP1A2CHRNA7KMT2A | |
| SCHEMBL5594895 | 0.81 | CHRNA7 (0.61) | CYP3A4CYP2C19CYP1A2CHRNA7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040063742-A1 | Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity | NEUROSEARCH A/S (DK) | 2004-04-01 | — | — | US | claimed |
| US-20040063742-A1 | Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity | NEUROSEARCH A/S (DK) | 2004-04-01 | — | — | US | disclosed |