SCHEMBL5595366

SCHEMBL5595366

c1cncc(CNCCCN2CCNCC2)c1

nearest known ligand 0.71

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 3/20 0.59
CYP3A4 P08684 2/20 0.59
CHRM2 P08172 1/20 0.58
CYP1A2 P05177 1/20 0.51
CYP2C19 P33261 1/20 0.50
ALDH1A1 P00352 2/20 0.49
ALOX15 P16050 1/20 0.49
TSHR P16473 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
SIGMAR1 Q99720 1/20 0.48
SCN8A Q9UQD0 1/20 0.47
NAMPT P43490 1/20 0.45
NPSR1 Q6W5P4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8018941 0.92 CYP2D6 (0.70) CYP2D6CYP3A4CHRM2CYP1A2ALDH1A1
SCHEMBL2447494 0.90 CHRM2 (0.67) CYP2D6CYP3A4CHRM2CYP1A2CYP2C19
SCHEMBL5714998 0.82 SIGMAR1 (0.67) ALDH1A1ALOX15L3MBTL1SIGMAR1
SCHEMBL26708792 0.81 CYP2D6 (0.55) CYP2D6CYP3A4CHRM2CYP1A2ALDH1A1
Hydrochloric Acid SCHEMBL15103010 0.81 SIGMAR1 (0.65) ALDH1A1ALOX15L3MBTL1SIGMAR1
SCHEMBL4773788 0.79 CCR3 (0.55) SIGMAR1
SCHEMBL4832659 0.79 SIGMAR1 (0.53) CYP2D6CYP3A4SIGMAR1
SCHEMBL30761594 0.79 SIGMAR1 (0.53) CYP2D6CYP3A4SIGMAR1
SCHEMBL6538443 0.78 DPP7 (0.65) CYP2D6CYP3A4CHRM2CYP1A2ALDH1A1
SCHEMBL11594897 0.78 CHRM2 (0.93) CYP2D6CHRM2CYP1A2ALDH1A1SCN8A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1809288-A1 USE OF 1,4-BIS (3-AMINOALKYL) PIPERAZINE DERIVATIVES IN THE TREATMENT OF NEURODEGENERATIVE DISEASES INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2007-07-25 EP claimed
WO-2006051489-A1 USE OF 1,4-BIS (3-AMINOALKYL) PIPERAZINE DERIVATIVES IN THE TREATMENT OF NEURODEGENERATIVE DISEASES INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2006-05-18 WO claimed
EP-1809288-A1 USE OF 1,4-BIS (3-AMINOALKYL) PIPERAZINE DERIVATIVES IN THE TREATMENT OF NEURODEGENERATIVE DISEASES INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2007-07-25 EP disclosed
WO-2006051489-A1 USE OF 1,4-BIS (3-AMINOALKYL) PIPERAZINE DERIVATIVES IN THE TREATMENT OF NEURODEGENERATIVE DISEASES INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2006-05-18 WO disclosed