Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2446278 | 0.91 | KDM4E (0.65) | KDM4EPOLB | |
| SCHEMBL5595516 | 0.83 | CHRM2 (0.57) | KDM4E | |
| SCHEMBL13068843 | 0.82 | SIGMAR1 (0.62) | — | |
| SCHEMBL6625725 | 0.80 | SIGMAR1 (0.63) | — | |
| Hydrochloric Acid SCHEMBL1332052 | 0.79 | SIGMAR1 (0.61) | — | |
| SCHEMBL5604920 | 0.77 | SLC6A4 (0.64) | — | |
| SCHEMBL29756433 | 0.77 | CYP1A2 (0.57) | KDM4ETP53 | |
| SCHEMBL4324560 | 0.77 | CYP1A2 (0.57) | KDM4ETP53 | |
| SCHEMBL11841171 | 0.77 | CYP1A2 (0.57) | KDM4ETP53 | |
| SCHEMBL5595644 | 0.76 | CYP3A4 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809288-A1 | USE OF 1,4-BIS (3-AMINOALKYL) PIPERAZINE DERIVATIVES IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006051489-A1 | USE OF 1,4-BIS (3-AMINOALKYL) PIPERAZINE DERIVATIVES IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2006-05-18 | — | — | WO | disclosed |