Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | KCNH3 | Q9ULD8 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5596734 | 0.89 | ALDH1A1 (0.40) | KCNH3ALDH1A1HPGDPOLBCDK1 | |
| SCHEMBL1751627 | 0.82 | HRH4 (0.42) | KCNH3ALDH1A1HPGDAXLFLT3 | |
| SCHEMBL5596514 | 0.82 | ALDH1A1 (0.42) | ALDH1A1HPGD | |
| SCHEMBL5596632 | 0.81 | DNM2 (0.42) | POLBRAD52KDM4ENPC1RAB9A | |
| SCHEMBL6027575 | 0.81 | DNM2 (0.43) | KCNH3ALDH1A1MERTKKDM4E | |
| SCHEMBL5762029 | 0.79 | ALDH1A1 (0.39) | ALDH1A1HPGDRAD52 | |
| SCHEMBL5759625 | 0.79 | ALDH1A1 (0.39) | ALDH1A1HPGDRAD52 | |
| SCHEMBL5762178 | 0.79 | ALDH1A1 (0.39) | ALDH1A1HPGDRAD52 | |
| SCHEMBL5596425 | 0.78 | CXCR4 (0.41) | ALDH1A1HPGD | |
| SCHEMBL5596716 | 0.78 | ALDH1A1 (0.40) | ALDH1A1HPGDFYNRAD52CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696909-B1 | BENZOTHIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES | SERONO LAB (CH) | 2007-11-14 | — | — | EP | claimed |
| EP-1418911-B1 | 2,4,5-TRISUBSTITUTED THIAZOLYL DERIVATIVES AND THEIR ANTIINFLAMMATORY ACTIVITY | JANSSEN PHARMACEUTICA NV (BE) | 2006-05-10 | — | — | EP | disclosed |
| EP-1418911-A1 | 2,4,5-TRISUBSTITUTED THIAZOLYL DERIVATIVES ANT THEIR ANTIINFLAMMATORY ACTIVITY | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-05-19 | — | — | EP | disclosed |
| WO-2003015776-A1 | 2,4,5-TRISUBSTITUTED THIAZOLYL DERIVATIVES AND THEIR ANTIINFLAMMATORY ACTIVITY | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-02-27 | — | — | WO | disclosed |