Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5417474 | 0.97 | ROCK2 (0.35) | ROCK2ROCK1GPBAR1SMYD3DRD2 | |
| SCHEMBL5415719 | 0.93 | ROCK2 (0.36) | ROCK2ROCK1GPBAR1SMYD3DRD2 | |
| SCHEMBL5596581 | 0.90 | ROCK2 (0.36) | ROCK2ROCK1GPBAR1GRIN2BDRD2 | |
| SCHEMBL5596822 | 0.89 | ROCK2 (0.36) | ROCK2ROCK1GPBAR1SMYD3GRIN2B | |
| SCHEMBL5415749 | 0.89 | ROCK2 (0.35) | ROCK2ROCK1GPBAR1SMYD3 | |
| SCHEMBL5420227 | 0.88 | ROCK2 (0.36) | ROCK2ROCK1GPBAR1DRD2 | |
| SCHEMBL5596659 | 0.88 | ROCK2 (0.36) | ROCK2ROCK1GPBAR1 | |
| SCHEMBL5410280 | 0.87 | ROCK2 (0.36) | ROCK2ROCK1GPBAR1SMYD3 | |
| SCHEMBL5596785 | 0.87 | ROCK2 (0.38) | ROCK2ROCK1GPBAR1DRD2 | |
| SCHEMBL5596968 | 0.87 | HTR2C (0.39) | ROCK2ROCK1GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1829876-A1 | NITROGENEOUS TRICYCLIC COMPOUND | Asahi Kasei Pharma Corporation (JP) | 2007-09-05 | — | — | EP | disclosed |