Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.34 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 4/20 | 0.32 |
| ▸ | NOS2 | P35228 | 3/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.32 |
| ▸ | NOS3 | P29474 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5420227 | 0.95 | ROCK2 (0.36) | ROCK2ROCK1CARM1PRMT6PRMT8 | |
| SCHEMBL5596581 | 0.95 | ROCK2 (0.36) | ROCK2ROCK1CARM1PRMT6PRMT8 | |
| SCHEMBL5596659 | 0.90 | ROCK2 (0.36) | ROCK2ROCK1OPRM1OPRD1OPRK1 | |
| SCHEMBL5415719 | 0.89 | ROCK2 (0.36) | ROCK2ROCK1OPRM1OPRD1OPRK1 | |
| SCHEMBL5410280 | 0.89 | ROCK2 (0.36) | ROCK2ROCK1OPRM1OPRD1OPRK1 | |
| SCHEMBL5407101 | 0.89 | VCP (0.37) | ROCK2ROCK1OPRM1OPRD1OPRK1 | |
| SCHEMBL5419735 | 0.88 | NOS1 (0.40) | ROCK2ROCK1OPRM1OPRD1OPRK1 | |
| SCHEMBL5415749 | 0.88 | ROCK2 (0.35) | ROCK2ROCK1OPRM1OPRD1OPRK1 | |
| SCHEMBL5417474 | 0.88 | ROCK2 (0.35) | ROCK2ROCK1OPRM1OPRD1OPRK1 | |
| SCHEMBL5596706 | 0.87 | ROCK2 (0.34) | ROCK2ROCK1GPBAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1632492-A1 | TRICYCLIC COMPOUND | Asahi Kasei Pharma Corporation (JP) | 2006-03-08 | — | — | EP | claimed |
| EP-1829876-A1 | NITROGENEOUS TRICYCLIC COMPOUND | Asahi Kasei Pharma Corporation (JP) | 2007-09-05 | — | — | EP | disclosed |