Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.46 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CSNK1A1L | Q8N752 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6440993 | 0.85 | PTGS2 (0.52) | PTGS2MAPK14ALDH1A1ALOX5CSNK1A1 | |
| SCHEMBL5144240 | 0.85 | MAPK14 (0.51) | MAPK14ALDH1A1ALOX5CSNK1A1CSNK1D | |
| SCHEMBL5500317 | 0.83 | SCD (0.54) | PTGS2MAPK14ALDH1A1ALOX5CSNK1A1 | |
| SCHEMBL5597026 | 0.81 | PTGS2 (0.53) | PTGS2MAPK14ALDH1A1ALOX5CSNK1A1 | |
| SCHEMBL5597148 | 0.80 | PTGS2 (0.50) | PTGS2MAPK14ALDH1A1ALOX5CSNK1A1 | |
| SCHEMBL6448446 | 0.80 | MAPK14 (0.64) | PTGS2MAPK14ALDH1A1ALOX5CSNK1A1 | |
| SCHEMBL5501473 | 0.79 | PTGS2 (0.50) | PTGS2MAPK14ALDH1A1ALOX5CSNK1A1 | |
| SCHEMBL7798253 | 0.78 | CBFB (0.56) | PTGS2MAPK14ALDH1A1ALOX5CSNK1A1 | |
| SCHEMBL8554519 | 0.77 | PTGS2 (0.47) | PTGS2MAPK14ALDH1A1ALOX5CSNK1A1 | |
| SCHEMBL6465182 | 0.77 | SCD (0.56) | PTGS2MAPK14ALDH1A1ALOX5CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1039914-A4 | CYCLOOXYGENASE-2 INHIBITION | CORNELL RES FOUNDATION INC (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20050009733-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a potassium ion channel modulator for the treatment of central nervous system damage | PHARMACIA CORPORATION | 2005-01-13 | — | — | US | disclosed |
| EP-1039914-A1 | CYCLOOXYGENASE-2 INHIBITION | CORNELL RESEARCH FOUNDATION, INC. (US) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999030721-A1 | CYCLOOXYGENASE-2 INHIBITION | CORNELL RESEARCH FOUNDATION, INC. (US) | 1999-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009733-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a potassium ion channel modulator for the treatment of central nervous system damage | KCNJ2, KCNN2, KCNK2 | PTGS2 4/4885MAPK14 1113/4885ALDH1A1 1789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.